Bortezomib Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease (GVHD) After Mismatched Allogeneic Non-Myeloablative Blood Stem Cell Transplantation

• In this study we are looking for the highest dose of Velcade that can be given to people safely when given with tacrolimus and methotrexate. Not everyone who participates in the study will receive the same amount of the study drug. The dose the participant will receive depends upon the number of subjects enrolled on the study and how well they have tolerated their doses of the drug.
• Before Transplant: In addition to the chemotherapy drugs, fludarabine and busulfex, for the participants non-myeloablative transplant, they will also start taking tacrolimus orally three days before their transplant.
• After Transplant Medication: Methotrexate; Intravenously on days 1, 3, 6 & 11 after transplant for a total of 4 doses. Tacrolimus; Continue taking orally once daily. Velcade: Intravenously on days 1, 4 & 7 after transplant, a total of 3 doses. Filgrastim: Subcutaneous injection daily starting the day after transplant and continuing until the participant blood counts have recovered.
• After Transplant Physical Exams & Tests: Participants will have physical exams and blood tests every week for 1 month. After 1 month, a none marrow biopsy will be performed to look for evidence of the donor's cells in the participants bone marrow.
• Following the 1 month period of time, participants will be seen every few weeks. Another bone marrow biopsy, as well as blood tests, will be taken 3-4 months after the transplant to review the disease status. At this point, participants will come into the clinic about every 3 months, or as determined by their physician for about one year.
• While the study ends at 12 months after transplant, we would like to keep track of the participants medical condition for the rest of their life.

Inclusion criteria

• Patients with hematologic malignancies including myelodysplastic syndrome (MDS), who are at a high risk of complications after myeloablative transplantation
• Patients have a donor (both related and unrelated) who are mismatched according to protocol criteria
• 18 years of age or older
• Performance status 0-2
• Life expectancy of > 100 days
• Female subject is either post-menopausal or sterilized or willing to use an acceptable form of birth control
• Male subject agrees to use an acceptable form of birth control

Exclusion criteria

• Evidence of HIV infection
• Total bilirubin > 2.0mg/dl that is due to hepatocellular dysfunction
• Aspartate aminotransferase (AST) > 90
• Known active hepatitis B or C
• Serum creatinine > 2.0
• Greater than or equal to Grade 2 peripheral neuropathy within 21 days of enrollment
• Prior allogeneic stem cell transplant
• Patients with myeloproliferative disease (e.g. myelofibrosis, essential thrombocythemia, polycythemia vera, chronic myeloid leukemia)
• Myocardial infarction within 6 months prior to enrollment or has NYHA Class III or IV hear failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities
• Hypersensitivity to Velcade, boron or mannitol
• Pregnant or breast feeding
• Patient has received other investigational drugs 14 days before enrollment
• Serious medical or psychiatric illness
• Another active solid tumor malignancy at the time of study entry