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Completed

NCT Number: NCT01907464

Bone Loss in Patients With Anorexia Nervosa

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.

160 patients (age < 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

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Key information

Conditions

Patients With Anorexia Nervosa Anorexia Nervosa Feeding and Eating Disorders Mental Disorders

Age range

14 year–38 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Montpellier - Département d'Endocrinologie Diabète

Montpellier, 34295, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Informed Consent
  • Health Insurance regimen or benefit from an health insurance regimen
  • Aged from 14 to 38 years old
  • Women
  • No pregnant

Specific inclusion criteria for patient:

Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

Specific inclusion criteria for controls:

  • Normal menstrual cycles,
  • No lifetime history of eating disorders,
  • BMI between 18 and 25 kg/m²

Exclusion criteria

  • use of treatments may be modify bone mass (bisphosphonates,…)
  • Disease or treatment may be induce osteoporosis
  • In exclusion period in relation with another study
  • Law protected subject

Treatment and study plan

clinical parameters description

Other

description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms

para clinical parameters description

Other

description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms

hormonal parameters dosing

Other

dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms

bone modeling markers dosing

Other

dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms

Primary outcomes

  1. Dual-X-ray absorptiometry (DEXA)

    Time frame: at Day 0 (time of the inclusion visit)

    The primary outcome is to model the bone mass acquisition in young women with anorexia nervosa.

Secondary outcomes

  1. Biological parameters identification

    Time frame: At day 0 (time of the inclusion visit)

    One of the secondary outcome is to identify biological factors associated with bone demineralisation.

  2. clinical parameters identification

    Time frame: At Day 0 (at time of the the inclusion visit)

    One of the secondary outcome is to identify the clinical factors associated with bone demineralisation.

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Physiopathology of Bone Loss in Young Patient With Anorexia Nervosa

Important dates

Study start
2011
Primary completion
2017
Study completion
2017
First posted
Jul 25, 2013
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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