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NCT Number: NCT07669103

Bone Cancer Surgery Prospective Database

According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050. Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023. Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis. Surgical resection is the main treatment method for both primary and secondary bone cancer. For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma. The incidence of postoperative complications remains high. The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life. Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.

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Key information

Conditions

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Zhejiang University anesthesiology department

Hangzhou, Zhejiang, 310000, China

Location contact

Min Yan, Doctor

CONTACT

[email protected]

+86 15888210247

Min Yan, Doctor

PRINCIPAL_INVESTIGATOR

About this study

At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.

Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of bone cancer
  • Scheduled to undergo elective bone cancer resection surgery

Exclusion criteria

  • Unable to comply with follow-up
  • declined participation in the study

Treatment and study plan

Bone cancer surgery

Procedure

patients receive surgery based on the doctor's discretion and the consideration of the patients and their family

Primary outcomes

  1. Complication

    Time frame: hospital discharge, an average of 10 days

    This includes embolic events, pulmonary complication, wound complication, acute kidney injury, death. Diagnose according to radiologic examination, sign and symptom

Secondary outcomes

  1. The rate of perioperative transfusion of allogeneic blood products

    Time frame: hospital discharge, an average of 10 days

    This includes blood products such as plasma and platelets, erythrocytes

  2. Wound drainage volume

    Time frame: hospital discharge, an average of 10 days

    Accumulated postoperative wound drainage volume

  3. The coagulation function tests during the perioperative period

    Time frame: hospital discharge, an average of 10 days

    This includes thromboelastography result

  4. Hemoglobin levels

    Time frame: hospital discharge, an average of 10 days

    Hemoglobin levels during hospitalIzation

  5. 6-month mortality

    Time frame: 6 months

  6. 1-year mortality

    Time frame: 1 year

  7. 2-year mortality

    Time frame: 2 years

  8. 3-year mortality

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Official study title

Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications

Important dates

Study start
2026
Primary completion
2026
Study completion
2028
First posted
Jun 25, 2026
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.