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Completed

NCT Number: NCT06240442

Bodyweight Interval Exercise in the Fed Versus Fasted State

The purpose of this study is to investigate the effects of a single session of at-home bodyweight interval exercise, performed in the fasted or fed state, on postprandial glycemic management, post-exercise fat oxidation, and overall perceptions of appetite in recreationally active females. This is a remote/online study and does not involve any visits to the laboratory.

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Key information

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S 2C9, Canada

About this study

Following the acquisition of informed consent via videoconferencing, eligibility to participate in the study will be determined using questionnaires. If inclusion criteria is met, participants will undergo virtual exercise familiarization by following a pre-recorded instructional video.

Eligible participants will be assigned, in a random order, to two metabolic trials at least 3 days apart in the follicular phase of the same menstrual cycle. These visits will be online with an investigator on videoconferencing. The two trials involve: 1) Exercise followed by breakfast; and 2) Breakfast followed by exercise.

Various outcomes will be measured throughout the metabolic trials including: blood sugar, fat oxidation and appetite. All research tools needed to acquire these methods will be delivered to participants' place of residence.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females 18-35 years
  • Recreationally active (complete <150 min of exercise 1-3 days per week) and not training for any specific sport
  • Experiencing monthly menstrual periods (eumenorrheic)
  • Are not currently on oral contraceptives, or are taking triphasic oral contraceptives
  • Body mass index (BMI) ≥18.5 kg/m2 and ≤30 kg/m2
  • Regular consumption of a breakfast meal (solid and liquid meals apply) most (≥ 4) days of the week
  • Have a device compatible for use with study applications (e.g., smart phone)

Exclusion criteria

  • Inability to safely perform physical activity as determined by the Get Active Questionnaire
  • Not willing to consume the standardized test drink before and after exercise
  • Sensitive to meal timing around exercise (e.g., gastrointestinal issues if exercise performed 10 min after the start of meal consumption or if a meal is consumed 5 min after exercise)
  • Inability to adhere to pre-trial protocol guidelines (e.g., caffeine or alcohol restrictions)
  • Physical limitations for bodyweight exercise
  • Are on monophasic or biphasic oral contraceptives
  • Regular tobacco or cannabis use (e.g., recreational and/or medical cannabis, cigarettes, e-cigarettes, vape pens, JUUL)
  • Regular use of drugs that may alter metabolism (e.g., corticosteroids, nSAIDs)
  • Diagnosed medical condition under the care of care of a physician (e.g., type 2 diabetes, cardiovascular disease) Currently enrolled in a course with Dr. Gillen

Treatment and study plan

Fasted exercise

Other

Bodyweight interval exercise performed 5 minutes before the start of a mixed-macronutrient breakfast meal

Fed exercise

Other

Bodyweight interval exercise performed 10 minutes after the start of consuming a mixed-macronutrient breakfast meal

Primary outcomes

  1. Average blood glucose concentration

    Time frame: 2 hours

    Average blood glucose concentration during postprandial period

Secondary outcomes

  1. Blood glucose concentration

    Time frame: 2 hours

    Blood glucose concentration across postprandial period

  2. Blood glucose area under the curve

    Time frame: 2 hours

    blood glucose area under the curve during postprandial period

  3. Peak blood glucose concentration

    Time frame: 2 hours

    peak glucose across postprandial period

  4. Post-exercise fat oxidation

    Time frame: pre-exercise, immediately post-exercise, up to 3 hours post-exercise

    post-exercise fat oxidation measured as percent carbon dioxide

  5. Appetite Perceptions

    Time frame: pre-exercise, immediately post-exercise, and 1, 2 and 3 hours post-exercise

    Visual analog scales (0-100) will be used to determine perceptions of hunger, satisfaction, fullness, and prospective food consumption with higher scores denoting increased perceptions.

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Registry information

Official study title

Bodyweight Interval Exercise in the Fed Versus Fasted State on Postprandial Glycemia, Appetite Perceptions and Fat Oxidation

Acronym: BWE

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Feb 5, 2024
Registry last updated
Feb 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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