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Completed

NCT Number: NCT06227260

Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit

This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.

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Key information

Conditions

Body Massage Oil From Snake Fruit Facial Mask From Snake Fruit Jelly From Snake Fruit

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Faculty of Allied Health Sciences, Burapha University

Mueang, Changwat Chon Buri, 20131, Thailand

About this study

Study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks.

Study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.

Study 3: this study was divided into 2 sub-stidies. Study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. All participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. After each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Man or woman
  • Aged between 18 to 35 years
  • Healthy
  • Interested in body massage with oil or facial mask or jelly from Snake fruit

Exclusion criteria

  • History of adverse effects from body massage
  • Skin allergy
  • Skin disorders
  • Skin wounds
  • History of allergy to coconut or plant oil
  • History of allergy to facial mask, i.e., mask from fruit
  • History of allergy to Snake fruit or gelatin
  • Signs or symptoms of fever or infection
  • Abnormal body mass index
  • Regular smokers or alcohol drinkers (>2 times per week)
  • Regular exerciser (>2 times per week or >150 min per week)
  • Regular intake of dietary supplements, i.e., vitamins, antioxidants
  • Hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer

Treatment and study plan

Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Other

Interventions among the 3 studies were categorized as other.

Primary outcomes

  1. Level of skin moisture

    Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

    Study 1 and 2 determined level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe

  2. Level of skin elasticity

    Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

    Study 1 and 2 determined level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe

  3. Level of skin oiliness

    Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

    Study 1 and 2 determined level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe

  4. Level of skin melanin

    Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

    Study 1 and 2 determined level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe

  5. Level of blood glucose

    Time frame: Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes

    Study 3.1 determined level of blood glucose in mg/dL unit

  6. Endurance time

    Time frame: After jelly consumption for 30 minutes

    Study 3.2 determined endurance time by cycling at 60% of maximum oxygen consumption as long as possible (time to exhaustion test)

  7. Concentration of interferon-gamma

    Time frame: Before and immediately after endurance time test

    Study 3.2 determined concentration of interferon-gamma in serum in pg (picogram)/mL unit

  8. Concentration of tumor necrosis factor-alpha

    Time frame: Before and immediately after endurance time test

    Study 3.2 determined concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit

Sponsors and collaborators

Lead sponsor

Burapha University

Other

Registry information

Official study title

Development and Evaluation of Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit (Salacca Edulis Reinw.)

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jan 26, 2024
Registry last updated
Jan 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.