BMI and Lymph Node Count in Colorectal Cancer

Background and aim: Colorectal Cancer (CRC) is one of the most frequent cancer entities in the western world. It is known that obesity is one of the major risk factors for CRC. In contrast, mild obesity seems to have a positive effect on postoperative outcome, which is known as the "obesity paradox". Also, the number of resected lymph nodes (LN) during surgery is very important for correct staging. The aim of the present project is to evaluate the impact of BMI and LN-yield on long term overall survival (OS) of CRC patients treated with curative intent.

Methods: Patients treated for CRC between 1998 and 2011 at the Klinik Favoriten in Vienna, Austria were analyzed in this retrospective single-center cohort analysis concerning OS.

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Key information

Conditions

The Aim of This Study is to Determine the Influence of BMI and Lymph Node Status on OS in CRC Patients in the Long Term Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik Floridsdorf

Vienna, 1210, Austria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

colorectal carcinoma
treated at the Klinik Favoriten between 1998 and 2011
elective or acute surgical setting
curative intent
older than 18 years

Exclusion criteria

other carcinoma (anal, metastases, ...)
treated before 1998 or after 2011
palliative intent
younger than 18 years

Treatment and study plan

no intervention, retrospective data analysis

Other

not applicable, retrospective data analysis

Primary outcomes

overall survival

Time frame: median follow up of 11.3 years

The aim of the present project is to evaluate the impact of BMI and LN-yield on long term overall survival (OS) of CRC patients treated with curative intent.

Sponsors and collaborators

Lead sponsor

Klinikum Floridsdorf

Other

Collaborators

Klinik Favoriten
Medical University of Vienna
Salzkammergut Klinikum Vöcklabruck

Registry information

Official study title

Prediction of Survival in Colorectal Cancer Patients on the Basis of Body Mass Index and Lymph Node Yield - a Retrospective Single Center Cohort Analysis Over a Quarter of a Century

Important dates

Study start: 2017
Primary completion: 2020
Study completion: 2020
First posted: Mar 28, 2024
Registry last updated: Mar 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed