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NCT Number: NCT06009809

Blood Velocity Variation in Right Renal and Superior Mesenteric Arteries During Cardio-pulmonary Bypass

The cardiopulmonary by-pass technique, used in cardiac surgery to obtain a bloodless operating field and an immobile heart, determines important effects on the blood vessel wall, especially when a continuous and non-continuous blood flow is used. In fact, a reduction in Nitric Oxide (NO) production by the endothelium, an increase in systemic vascular resistance and an increased risk of cerebral and renal hypoperfusion have been observed and can result in potential organ damage. Acute kidney injury (AKI) after heart surgery is a major cause of mortality and morbidity. Its incidence varies according to different definitions, but can reach 30%. In some series, 1-5% of patients require renal replacement therapy in the postoperative period presenting a mortality that can reach 50-70%. However, even more limited increases in serum creatinine are associated with worsening prognosis and the risk of chronic kidney disease. The pathophysiology of AKI in cardiac surgery is complex and still partly unknown.Recently a technique has been described that allows to measure the blood velocity in the right renal artery and in the superior mesenteric artery using the transesophageal echocardiogram (TEE); this technique allows to view these arteries and measure the speed of the blood with good precision because the insonation angle (ie the angle formed by the ultrasound flow and the direction of the blood vessel) is adequate. In cardiac surgery, this methodology allows you to monitor blood velocity in the right renal artery and superior mesenteric artery during surgery. Some authors have used it to conduct pilot studies in which the blood velocity values in the renal arteries during cardiac surgery were used to calculate the pulsatility and resistivity indices, as predictors of the risk of postoperative AKI. At present, therefore, despite the fact that TEE is routinely used for monitoring renal perfusion during cardiac surgery, the blood velocity in the renal and mesenteric arteries has been little studied during cardiopulmonary by-pass (CPB) and has never been evaluated during CPB with continuous flow; in particular, the possible variation in blood velocity measured during CPB compared to the baseline values measured before extracorporeal circulation and its correlation with the onset of postoperative renal failure is not known.

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Key information

Conditions

Heart Surgical Procedure Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

The cardiopulmonary by-pass (CPB) technique, used in cardiac surgery to obtain a bloodless operating field and an immobile heart, determines important effects on the blood vessel wall, especially when a continuous and non-continuous blood flow is used. In fact, a reduction in NO production by the endothelium, an increase in systemic vascular resistance and an increased risk of cerebral and renal hypoperfusion have been observed and can result in potential organ damage.

Acute kidney injury (AKI) after heart surgery is a major cause of mortality and morbidity. Its incidence varies according to different definitions, but can reach 30%. In some series, 1-5% of patients require renal replacement therapy (RRT) in the postoperative period presenting a mortality that can reach 50-70%. However, even more limited increases in serum creatinine (sCr) are associated with worsening prognosis and the risk of chronic kidney disease (CKD). The pathophysiology of AKI in cardiac surgery is complex and still partly unknown. It is believed that one of the main causative factors is hypoperfusion and renal hypoxia, in particular of the medullary region; this would result in a vasoconstriction of the afferent arterioles to the glomerulus and a reduction in filtration. Risk factors associated with the increased incidence of AKI include bleeding, use of the aortic pump, excessive cardiopulmonary bypass duration, excessive haemodilution, insufficient pump flow, or insufficient blood pressure. Hypothermia, which also has a protective effect against hypoperfusion and tissue hypoxia, could induce AKI by increasing renal vascular resistance and favoring medullary hypoxia during subsequent rewarming.

In addition to AKI, another complication of cardiac surgery, rarer but associated with a higher mortality, is acute mesenteric ischemia; the most frequent type is non-occlusive mesenteric ischemia (NOMI) which seems to have as a predisposing cause a reduction or maldistribution of splanchnic blood flow and the use of vasoconstrictors.

Recently a technique has been described that allows to measure the blood velocity in the right renal artery and in the superior mesenteric artery using the transesophageal echocardiogram (TEE); this technique allows to view these arteries and measure the speed of the blood with good precision because the insonation angle (ie the angle formed by the ultrasound flow and the direction of the blood vessel) is adequate. In cardiac surgery, this methodology allows you to monitor blood velocity in the right renal artery and superior mesenteric artery during surgery. Some authors have used it to conduct pilot studies in which the blood velocity values in the renal arteries during cardiac surgery were used to calculate the pulsatility and resistivity indices, as predictors of the risk of postoperative AKI. The calculation of these indices, however, requires the use of a pulsatile blood flow to generate a periodic variation of the blood velocity, and they are not evaluable during CPB since the current practice in almost all centers is to use a continuous blood flow. At present, therefore, despite the fact that TEE is routinely used for monitoring renal perfusion during cardiac surgery, the blood velocity in the renal and mesenteric arteries has been little studied during CPB and has never been evaluated during CPB with continuous flow; in particular, the possible variation in blood velocity measured during CPB compared to the baseline values measured before extracorporeal circulation and its correlation with the onset of postoperative renal failure is not known.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age> 18 years
  • written informed consent
  • cardiac surgery with cardiopulmonary bypass (CPB)
  • New York Heart Association (NYHA) class I, II, III
  • preoperative serum creatinine less than 1.2 mg / dl

Exclusion criteria

  • contraindications to Trans Esophageal Ultrasound (TEE) based on American Society of Anesthesiologists (ASA) recommendations (esophageal or gastric diseases or previous surgery)
  • history of non-coronary arterial pathologies
  • atrial fibrillation
  • preoperative serum creatinine greater than 1.2 mg / dl • NYHA class IV
  • emergency cardiac surgery

Treatment and study plan

transesophageal echocardiogram

Diagnostic Test

To measure mean blood velocity at the level of the right renal and superior mesenteric artery

Primary outcomes

  1. Comparison of right renal artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: Basal 1: up to 10 minutes after induction of anesthesia and placement of transesophageal probe

    Right renal artery mean blood velocity (cm/sec) before CPB

  2. Comparison of right renal artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: Basal 2: up to 30 minutes after sternotomy in conditions of hemodynamic stability

    Right renal artery mean blood velocity (cm/sec) before CPB

  3. Comparison of right renal artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 5 min: during CPB, 5 minutes after the end of the first cardioplegia

    Right renal artery mean blood velocity (cm/sec) during CPB

  4. Comparison of right renal artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 30 min: during CPB, 30 minutes after the end of the first cardioplegia

    Right renal artery mean blood velocity (cm/sec) during CPB

  5. Comparison of right renal artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 60 min: during CPB, 60 minutes after the end of the first cardioplegia

    Right renal artery mean blood velocity (cm/sec) during CPB

Secondary outcomes

  1. Comparison of superior mesenteric artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: Basal 1: up to 10 minutes after induction of anesthesia and placement of transesophageal probe

    Superior mesenteric artery mean blood velocity (cm/sec) before CPB

  2. Comparison of superior mesenteric artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: Basal 2: up to 30 minutes after sternotomy in conditions of hemodynamic stability

    Superior mesenteric artery mean blood velocity (cm/sec) before CPB

  3. Comparison of superior mesenteric artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 5 min: during CPB, 5 minutes after the end of the first cardioplegia

    Superior mesenteric artery mean blood velocity (cm/sec) during CPB

  4. Comparison of superior mesenteric artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 30 min: during CPB, 30 minutes after the end of the first cardioplegia

    Superior mesenteric artery mean blood velocity (cm/sec) during CPB

  5. Comparison of superior mesenteric artery mean blood velocities before and during cardiopulmonary by-pass (CPB)

    Time frame: CPB 60 min: during CPB, 60 minutes after the end of the first cardioplegia

    Superior mesenteric artery mean blood velocity (cm/sec) during CPB

  6. Correlation between mean blood velocity values and hemodynamic parameters: cardiopulmonary by-pass (CPB) blood flow

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and CPB blood flow (L/min)

  7. Correlation between mean blood velocity values and CPB blood flow

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and CPB blood flow (L/min)

  8. Correlation between right renal artery mean blood velocity values and CPB blood flow

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and cardiopulmonary by-pass blood flow (L/min)

  9. Correlation between superior mesenteric artery mean blood velocity values and cardiopulmonary by-pass (CPB) blood flow

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and cardiopulmonary by-pass blood flow (L/min)

  10. Correlation between superior mesenteric artery mean blood velocity values and CPB blood flow

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia, during cardiopulmonary by-pass

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and cardiopulmonary by-pass blood flow (L/min)

  11. Correlation between superior mesenteric artery mean blood velocity values and CPB blood flow

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and cardiopulmonary by-pass blood flow (L/min)

  12. Correlation between right renal artery mean blood velocity values and hemodynamic parameters (mean arterial pressure, MAP)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and mean arterial pressure (mmHg)

  13. Correlation between right renal artery mean blood velocity values and MAP

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and MAP (mmHg)

  14. Correlation between right renal artery mean blood velocity values and MAP

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right arterial mean blood velocity (cm/sec) and mean arterial pressure (mmHg)

  15. Correlation between superior mesenteric artery mean blood velocity values and hemodynamic parameters (mean arterial pressure, MAP)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and MAP (mmHg)

  16. Correlation between superior mesenteric artery mean blood velocity values and MAP

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and mean arterial pressure (mmHg)

  17. Correlation between superior mesenteric artery mean blood velocity values and MAP

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and MAP (mmHg)

  18. Correlation between right renal artery mean blood velocity values and laboratory parameters (arterial PCO2)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  19. Correlation between right renal artery mean blood velocity values and laboratory parameters (arterial PCO2)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  20. Correlation between right renal artery mean blood velocity values and arterial PCO2

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  21. Correlation between superior mesenteric artery mean blood velocity values and laboratory parameters (arterial PCO2)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  22. Correlation between superior mesenteric artery mean blood velocity values and laboratory parameters (arterial PCO2)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  23. Correlation between superior mesenteric artery mean blood velocity values and arterial PCO2

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial PCO2 (mmHg)

  24. Correlation between right renal artery mean mean blood velocity values and laboratory parameters (Hematocrit)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and hematocrit

  25. Correlation between right renal artery mean mean blood velocity values and laboratory parameters (Hematocrit)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and hematocrit

  26. Correlation between right renal artery mean mean blood velocity values and laboratory parameters (Hematocrit)

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and hematocrit

  27. Correlation between superior mesenteric artery mean mean blood velocity values and laboratory parameters (Hematocrit)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and hematocrit

  28. Correlation between superior mesenteric artery mean mean blood velocity values and Hematocrit

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and hematocrit

  29. Correlation between superior mesenteric artery mean mean blood velocity values and Hematocrit

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and hematocrit

  30. Correlation between right renal artery mean blood velocity values and Temperature

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and Temperature (Celsius degrees)

  31. Correlation between right renal artery mean blood velocity values and Temperature

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and Temperature (Celsius degrees)

  32. Correlation between right renal artery mean blood velocity values and Temperature

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and Temperature (Celsius degrees)

  33. Correlation between superior mesenteric artery mean blood velocity values and Temperature

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and Temperature (Celsius degrees)

  34. Correlation between superior mesenteric artery mean blood velocity values and Temperature

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and Temperature (Celsius degrees)

  35. Correlation between superior mesenteric artery mean blood velocity values and Temperature

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and Temperature (Celsius degrees9

  36. Correlation between right renal artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and negative pressure applied to the venous drainage (vacuum-assist venous drainage) (mmHg)

  37. Correlation between right renal artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and VAVD (mmHg)

  38. Correlation between right renal artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 60 min: during CPB, 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and VAVD (mmHg)

  39. Correlation between superior mesenteric artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between superior mesenteric artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD) (mmHg)

  40. Correlation between superior mesenteric artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD) (mmHg)

  41. Correlation between superior mesenteric artery mean blood velocity values and negative pressure applied to the venous drainage (vacuum-assist venous drainage, VAVD)

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity values and VAVD (mmHg)

  42. Correlation between right renal artery mean blood velocity values and laboratory parameters (arterial lactate)

    Time frame: CPB 5 min: 5 minutes after the end of the first cardioplegia, during CPB

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  43. Correlation between right renal artery mean blood velocity values and laboratory parameters (arterial lactate)

    Time frame: CPB 30 min: 30 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  44. Correlation between right renal artery mean blood velocity values and laboratory parameters (arterial lactate)

    Time frame: CPB 60 min: 60 minutes after the end of the first cardioplegia

    Correlation between right renal artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  45. Correlation between superior mesenteric artery mean blood velocity and laboratory parameters (arterial lactate)

    Time frame: CPB 5 min: during CPB, 5 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  46. Correlation between superior mesenteric artery mean blood velocity and laboratory parameters (arterial lactate)

    Time frame: CPB 30 min: during CPB, 30 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  47. Correlation between superior mesenteric artery mean blood velocity and laboratory parameters (arterial lactate)

    Time frame: CPB 60 min: during CPB, 60 minutes after the end of the first cardioplegia

    Correlation between superior mesenteric artery mean blood velocity (cm/sec) and arterial lactate (mmol/L)

  48. Correlation between right renal artery mean blood velocity values during CPB and Acute Kidney Injury (AKI)

    Time frame: CPB 5 min: during CPB, 5 minutes after the end of the first cardioplegia

    Comparison between right renal artery mean blood velocity (cm/sec) measured during CPB in patients who develop AKI according Kidney Disease Improving Global Outcomes (KDIGO) definition (AKI group) and in patients who don't develop AKI (non AKI group) during the postoperative period

  49. Correlation between right renal artery mean blood velocity values during CPB and Acute Kidney Injury (AKI)

    Time frame: CPB 30 min: during CPB, 30 minutes after the end of the first cardioplegia

    Comparison between right renal artery mean blood velocity (cm/sec) measured during CPB in patients who develop AKI according KDIGO definition (AKI group) and in patients who don't develop AKI (non AKI group) during the postoperative period

  50. Correlation between right renal artery mean blood velocity values during CPB and Acute Kidney Injury (AKI)

    Time frame: CPB 60 min: during CPB, 60 minutes after the end of the first cardioplegia

    Comparison between right renal artery mean blood velocity (cm/sec) measured during CPB in patients who develop AKI according KDIGO definition (AKI group) and in patients who don't develop AKI (non AKI group) during the postoperative period

  51. Evaluation of serum Cystatin C in low right renal artery mean blood velocity during CPB

    Time frame: Postoperative day 1: 24 hours after the end of the cardiopulmonary by-pass

    Comparison between serum Cystatin C mean level (mg/L) measured in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) right renal artery blood velocity (cm/sec) measured during CPB

  52. Evaluation of urinary Neutrophil Gelatinase-associated Lipocalin (uNGAL) in low right renal artery mean blood velocity

    Time frame: Immediate postoperative period: 4 hours after the end of the cardiopulmonary by-pass

    Comparison between urinary uNGAL mean level (ng/ml) measured immediately after surgery in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) right renal artery blood velocity (cm/sec) during CPB

  53. Evaluation of urinary Neutrophil Gelatinase-associated Lipocalin (uNGAL) in low right renal artery mean blood velocity

    Time frame: Postoperative day 1: 24 hours after the end of the cardiopulmonary by-pass

    Comparison between urinary uNGAL mean level (ng/ml) measured on the first postoperative day in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) right renal artery blood velocity (cm/sec) during CPB

  54. Evaluation of lactate in patients with low superior mesenteric artery mean blood velocity values

    Time frame: Immediate postoperative period: 4 hours after the end of the cardiopulmonary by-pass

    Comparison between mean arterial lactate (mmol/L) measured immediately after surgery in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) superior mesenteric artery blood velocity (cm/sec) during CPB

  55. Evaluation of lactate in patients with low superior mesenteric artery mean blood velocity

    Time frame: Postoperative day 1: 24 hours after the end of the cardiopulmonary by-pass

    Comparison between arterial lactate (mmol/L) measured on the first postoperative day in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) superior mesenteric artery mean blood velocity (cm/sec) measured during CPB

  56. Evaluation of amylase in low superior mesenteric artery mean blood velocity

    Time frame: Immediate postoperative period: 4 hours after the end of the cardiopulmonary by-pass

    Comparison between mean serum amylase (UI/L) measured immediately after surgery in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) superior mesenteric artery blood velocity (cm/sec) measured during CPB

  57. Evaluation of amylase in low superior mesenteric artery mean blood velocity

    Time frame: Postoperative day 1: 24 hours after the end of the cardiopulmonary by-pass

    Comparison between mean serum amylase (UI/L) measured on the first postoperative day in patients with low (below the 25th percentile) and in patients with higher (above 25th percentile) superior mesenteric artery blood velocity (cm/sec) measured during CPB

  58. Feasibility of measurement of right renal artery blood velocity during CPB

    Time frame: During CPB

    the number of patients in whom is possible to measure right renal artery blood velocity during CPB

  59. Feasibility of measurement of superior mesenteric artery blood velocity during CPB

    Time frame: During CPB

    the number of patients in whom is possible to measure superior mesenteric artery blood velocity during CPB

Study contacts

Contact information is provided by the study sponsor or research team.

Gabriella Arlotta, M.D.

CONTACT

[email protected]

+390630154848

Temistocle Taccheri, M.D.

CONTACT

[email protected]

+390630154848

Sponsors and collaborators

Lead sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Other

Registry information

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Aug 24, 2023
Registry last updated
Dec 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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