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NCT Number: NCT07271420

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

Recruiting

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Key information

Conditions

Hypertension Cardiovascular Diseases Chronic Disease Disease Attributes End Stage Kidney Disease (ESRD) Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Peritoneal Dialysis Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Prince of Wales Hospital. The Chinese University of Hong Kong

Hong Kong

Location status: Recruiting

Location contact

CC Szeto, MD, FRCP

CONTACT

[email protected]

0085235052211

About this study

This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg).

Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg)

Exclusion criteria

  • Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months

Treatment and study plan

Hydrochlorothiazide 25mg once per day

Drug

Thiazides diuretics

Primary outcomes

  1. Change in systolic and diastolic blood pressure

    Time frame: 90 days

Secondary outcomes

  1. Changes in body weight

    Time frame: 90 days

  2. Changes in body composition measured by bio impedance spectroscopy

    Time frame: 90 days

  3. Change in urinary fractional excretion of sodium

    Time frame: 90 days

Study contacts

Contact information is provided by the study sponsor or research team.

Gordon Chan, MD, MRCP

CONTACT

[email protected]

0085235052211

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Important dates

Study start
2020
Primary completion
2026
Study completion
2027
First posted
Dec 9, 2025
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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