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OpenTrials
Completed

NCT Number: NCT01428609

Blood Mercury Levels Following Retrograde Amalgam Surgeries

The aim of this study is to determine the blood's mercury level of patients who had amalgam root end filling surgeries. It is to be examined if the mercury concentration in blood is elevated by using amalgam retroseal.

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Key information

Conditions

Blood Mercury Concentration

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

School of Dentistry, Isfahan University of Medical Sciences

Isfahan, 8174673461, Iran

About this study

  • A total of 14 patients who needs surgical root canal therapy (SRCT) participated in this clinical study.
  • The Isfahan University Human Subjects Review Committee approved the protocol of the study.
  • All patients filled in the consent form.
  • Apicoectomy with retrograde amalgam filling performed for all participant.
  • Blood samples were collected in three period of time immediately before and immediately after each surgery and also one week later.
  • Each time 10 ml blood was drawn from each patient.
  • Analysis of total mercury in blood samples was performed using cold-vapor atomic absorption spectrometry

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • older than 18 years
  • without physician-diagnosed psychological, behavioral, neurological, immunosuppressive, or renal disorders
  • having a tooth that required apical surgery

Exclusion criteria

  • using tobacco and alcohol one week before surgery and during the study
  • dealing with mercury in their job like dentists, stonemason, mine workers

Treatment and study plan

Amalgam

Procedure

In all surgical intervention a zinc free amalgam (Tytin. Kerr Sybron Crop., Romulus, MI) was used in the root end prepared spaces as root end filling material. Blood samples were collected in three period of time immediately before and immediately after each surgery and also one week later.

Other names: cold-vapor atomic absorption spectrometry(Shimadzu, AA-10)

Primary outcomes

  1. Blood mercury concentration

    Time frame: within the 7 days after surgery

Sponsors and collaborators

Lead sponsor

Masoud Saatchi

Other

Collaborators

  • Isfahan University of Medical Sciences

Registry information

Important dates

Study start
2009
Primary completion
2009
Study completion
2010
First posted
Sep 5, 2011
Registry last updated
Mar 22, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.