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NCT Number: NCT03015350

Blood Levels of Sevoflurane and Desflurane

16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

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Key information

Conditions

Anesthetics, Inhalation Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ebru Biricik

Adana, In the USA Or Canada, Please Select..., 01380, Turkey (Türkiye)

About this study

Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA I-II patients

  • Who undergo thoracotomy or abdominal surgery

Exclusion criteria

  • ASA IV and up patients
  • Patients who taken inotropic agent

Treatment and study plan

Sevoflurane

Drug

Measurement of blood desflurane level during one lung ventilation

Other names: Blood sevoflurane level

Desflurane

Drug

Measurement of blood desflurane level during one lung ventilation

Other names: Blood desflurane level

Primary outcomes

  1. Measurement of blood levels of Sevoflurane and Desflurane

    Time frame: from 40th minute to the end of the operation

    Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.

Secondary outcomes

  1. determine of ventilation-perfusion mismatch with p(A-a)O2

    Time frame: from 40th minute to the end of the one lung ventilation

    During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Official study title

Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jan 10, 2017
Registry last updated
Mar 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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