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NCT Number: NCT07344740

Blood Flow Restriction Resistance Exercise and Cardiac Cycle Dynamics

Blood flow restriction resistance exercise uses partial vascular occlusion of a limb during low weight resistance exercises to stimulate muscle strengthening and growth. This is commonly used during rehabilitation from an injury. Because blood flow in and out of the limbs is decreased, this may have consequences for blood flow through the heart. The purpose of this study will be to test cardiac dynamics during blood flow restriction resistance exercise to determine if cardiac blood flow is impacted. It is hypothesized that both non-BFR exercise and BFR exercise will increase heart rate shortening various cardiac cycle parameters, but BFR exercise will increase the isovolumetric contraction time vs non-BFR exercise due to an increase in total peripheral resistance. It is also hypothesized that BFR exercise will lower early ventricular filling parameters due to lower venous return.

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Key information

Conditions

Cardiac

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Generally healthy

Exclusion criteria

  • Uncontrolled hypertension
  • Peripheral vascular disease
  • Lymphedema
  • Sickle cell anemia
  • Heart failure
  • Stroke history
  • Heart attack history
  • Rheumatoid arthritis
  • Chronic kidney disease
  • Diabetes
  • Severe neuropathy
  • Any condition that may make blood flow restriction resistance exercise riskier like history of blood clots
  • Use of coagulant therapy
  • Susceptible to blood clots
  • Obesity

Treatment and study plan

Blood flow restriction resistance exercise

Behavioral

Blood flow in and out of the limb will be artificially with an occlusion cuff.

Primary outcomes

  1. Cardiac cycle durations

    Time frame: During the intervention for approximately 10 minutes.

  2. Ventricular filling

    Time frame: During intervention phase for approximately 10 minutes.

Study contacts

Contact information is provided by the study sponsor or research team.

Evan Matthews

CONTACT

[email protected]

17406328709

Sponsors and collaborators

Lead sponsor

Montclair State University

Other

Registry information

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jan 15, 2026
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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