Blood Donor CVD 5000

Inclusion criteria

• Age 18 years and older
• Good general health as determined by a screening evaluation within 28 days before blood donation
• Informed, written consent

Exclusion criteria

• History of any of the following medical illnesses:

• Diabetes
• Cancer in past 5 years (except for basal cell carcinoma of the skin and cervical carcinoma in situ)
• Heart disease (Hospitalization for a heart attack, coronary artery bypass graft, arrhythmia, or syncope, within past 5 years. Current symptoms of heart disease - dyspnea, angina, orthopnea)
• Recurrent infections (more than 3 hospitalizations for invasive bacterial infections such as pneumonia or meningitis)
• Current drug or alcohol abuse
• Active ulcer disease or ongoing intestinal condition
• Treatment for anemia in last 6 months
• Currently being treated with anti-malarial drugs
• Any of the following laboratory abnormalities detected during medical screening:

• WBC <0.81 x LLN or > 1.09 x ULN
• Hemoglobin <0.91 x LLN or >1.18 x ULN (women) or <0.92 x LLN or >1.18 x ULN (men)
• Platelet count <0.8 x LLN or > 1.2 x ULN
• (For leukopheresis or blood unit donations, the following lab values are exclusionary:
• WBC <3.5 or >11 x 103/mm3;
• Hemoglobin <12.5 or >18 g/dl
• Platelet count <150 or >500 x 103/mm3)
• SGOT or SGPT >1.5 times normal
• Positive serology for hepatitis C or HIV antibody or hepatitis B surface antigen
• Positive serology for hepatitis B core antibody
• Poor peripheral venous access for blood donation
• Positive RPR
• Other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or interfere with the scientific integrity of study.
• Positive urine pregnancy test (HCG) on day of vaccination. Prior to each blood donation -females with menstrual history consistent with pregnancy. Pregnant women will not be enrolled, because immunological changes that occur during pregnancy may interfere with laboratory assays.