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OpenTrials
Completed

NCT Number: NCT00185003

Blockade of Vascular Potassium Channels During Human Endotoxemia

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

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Key information

Conditions

Endotoxemia Bacteremia Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome Toxemia

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers

Exclusion criteria

  • drug, alcohol, nicotine abuse

Treatment and study plan

Endotoxin

Drug

Potassium channel blockers: TEA, Quinin, Tolbutamide

Drug

L-NMMA

Drug

Primary outcomes

  1. Hemodynamics

    Time frame: 24 hrs after LPS administration

  2. Markers of Inflammation

    Time frame: 24 hrs after LPS administration

  3. Cytokines

    Time frame: 24 hrs after LPS administration

  4. Markers of Renal Injury

    Time frame: 24 hrs after LPS administration

  5. Inducible NO synthase expression

    Time frame: 24 hrs after LPS administration

  6. NO-metabolites

    Time frame: 24 hrs after LPS administration

  7. Mediators of Vascular reactivity

    Time frame: 24 hrs after LPS administration

  8. Sensitivity to norepinephrine

    Time frame: 24 hrs after LPS administration

Sponsors and collaborators

Lead sponsor

Radboud University Medical Center

Other

Collaborators

  • ZonMw: The Netherlands Organisation for Health Research and Development

Registry information

Important dates

Study start
2003
Primary completion
2005
Study completion
2005
First posted
Sep 16, 2005
Registry last updated
Oct 17, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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