Bleeding Prediction in Thrombocytopenia

The purpose of the study is to investigate whether platelet indices from automated haematology equipment, whole blood impedance aggregometry and a standardized bleeding questionnaire predict bleeding in admitted patients with thrombocytopenia of various causes.

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Key information

Conditions

Thrombocytopenia Blood Platelet Disorders Cytopenia Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

About this study

Thrombocytopenia is a risk factor for bleeding, but studies concerning markers for stratification of bleeding risk among thrombocytopenic patients are lacking. This prospective observational cohort study investigates risk factor for bleeding in admitted patients with thrombocytopenia of various causes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Admitted patients with thrombocytopenia
Age ≥18 years
Platelet count below 80 x109/L

Exclusion criteria

Platelet transfusion within the previous 14 days,
surgery or trauma within the previous 7 days
Unable to give informed consent.

Treatment and study plan

Primary outcomes

Mean platelet volume

Time frame: 30 days

Mean platelet volume (femtolitre (fL))

Secondary outcomes

Platelet count

Time frame: 30 days

Platelet count ( x10'9/L)
immature platelet fraction

Time frame: 30 days

immature platelet fraction (%)
Bleeding questionnaire

Time frame: 30 days

Bleeding score based on the condensed MCMDM-1 VWD bleeding questionnaire
Platelet aggregation

Time frame: 30 days

Platelet aggregation by Multiplate Analyzer (aggregation units* min)

Sponsors and collaborators

Lead sponsor

Pernille Just Vinholt

Other

Registry information

Official study title

Bleeding Prediction in Thrombocytopenia Using Platelet Indices, Platelet Aggregometry and a Standardized Bleeding Questionnaire

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: Dec 3, 2014
Registry last updated: Aug 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed