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NCT Number: NCT06719583

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities.

BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alabama at Birmingham, Birmingham, Alabama, United States

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About this study

Research studies have found connections between genes and Parkinson's disease (PD). But those results have mostly come from studies with non-Black or African American volunteers. BLAAC PD aims to learn more about gene changes that may cause Parkinson's in Black and African American people. Study volunteers at sites across the United States will attend one visit and will give either a blood or saliva sample, complete a smell test, and may be asked to complete a physical exam. This new data could lead to future Parkinson's tests and treatments for Black and African American people and it may help better understand disease in other groups, too.

This pioneering initiative will fill a gap of knowledge about PD in Black and African American people.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for Control Participants:

  • Ability to provide informed consent
  • Age 50 years or older
  • Self-identify as Black or African American

Exclusion criteria

for Control Participants:

  • Diagnosis of Parkinson's Disease and/or neurological condition
  • Familial history of PD and/or neurodegenerative or psychiatric conditions
  • Unknown family history of PD and/or neurodegenerative or psychiatric conditions
  • Any conditions that, in the investigator's opinion, preclude the individual's ability to carry out study activities
  • If submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection

Inclusion criteria

for Participants with a Diagnosis of PD:

  • Ability to provide informed consent
  • Age 18 years or older
  • Self-identify as Black or African American
  • Meet the Movement Disorder Society's clinical diagnostic criteria for Parkinson's disease

Exclusion criteria

for Participants with a Diagnosis of PD:

  • If submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection

Treatment and study plan

Primary outcomes

  1. Explore novel risk factors and characterization

    Time frame: 5 years

    To explore novel risk factors and characterization of known genetic risk factors contributing to Parkinson's disease risk in the Black and African American population.

Study contacts

Contact information is provided by the study sponsor or research team.

Naomi Louie, MPH RDN

CONTACT

[email protected]

212-509-0995 ext. 354

Sponsors and collaborators

Lead sponsor

Michael J. Fox Foundation for Parkinson's Research

Other

Collaborators

  • Indiana University
  • Louisiana State University Health Sciences Center Shreveport
  • Medical University of South Carolina
  • Ochsner Health System
  • Rush University
  • The University of Texas Health Science Center, Houston
  • University Hospitals Cleveland Medical Center
  • University of Alabama at Birmingham
  • University of Chicago
  • University of Florida
  • University of Maryland
  • Washington University School of Medicine

Registry information

Official study title

Black and African Americans Connections to Parkinson's Disease (BLAAC PD) A Project of the Global Parkinson's Genetics Program (GP2)

Acronym: BLAAC PD

Important dates

Study start
2020
Primary completion
2027
Study completion
2027
First posted
Dec 6, 2024
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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