Bisphenol Role in the Pathogenesis of PCOS

Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria .

Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..

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Key information

Conditions

PCOS

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Algazeerah

Giza, Egypt

About this study

Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites .

Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid .

Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age group: 18-40
Females
Diagnosed a case of polycystic ovary syndrome

Exclusion criteria

• Female patients with other acute or chronic illness

Cardiovascular disease
Neoplasms
Current smoking, diabetes mellitus,
Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood pressure 140/85 mm Hg).

Treatment and study plan

Measurement of Bisphenol in urine

Diagnostic Test

to see level of this material in blood of women

Primary outcomes

the number of participants who will have high level of bisphenol in btheir blood

Time frame: within 6 weeks

Sponsors and collaborators

Lead sponsor

Aljazeera Hospital

Other

Collaborators

Cairo University
Kasr El Aini Hospital

Registry information

Official study title

Role of Bisphenol A (BPA) in the Pathogenesis of the Polycystic Ovary Syndrome

Important dates

Study start: 2019
Primary completion: 2019
Study completion: 2020
First posted: Feb 19, 2018
Registry last updated: Jan 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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