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Completed

NCT Number: NCT07718256

Bipolar Enucleation of the Prostate Versus Bipolar TURP

Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large prostates above 80 gm.

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Key information

Age range

40 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Ain Shams university hospitals

Cairo, Cairo Governorate, 11566, Egypt

About this study

Recent literature suggests that enucleation techniques may provide superior functional results, reduced bleeding, and lower retreatment rates. Nevertheless, there remains limited high-quality randomized controlled data directly comparing bipolar TURP and bipolar enucleation of prostate as a head to head comparison regarding functional outcomes and peri-operative complications.

In this study, a randomized controlled trial was performed to compare bipolar enucleation of the prostate versus bipolar transurethral resection of the prostate in BPH regarding symptoms relief, residual adenoma, urine flow rate and post-operative morbidity.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All male patients above the age of 40 years who presented to the urology clinic in Ain Shams university hospitals with BPH with prostate size 80 - 120 g and have any of the following criteria:
  • Voiding symptoms that are poorly responsive to medical treatment (IPSS more than 18 and Qmax less than 15 ml/sec)
  • Persistent or recurrent attacks of urine retention due to BPH.
  • Large bladder stones from BPH.
  • Recurrent UTI due to BPH.
  • Severe gross hematuria from BPH.

Exclusion criteria

  • Patients with untreated or active UTI.
  • Previous pelvic radiation or pelvicl trauma.
  • Patients with anesthesia contraindications such as uncontrolled diabetes mellitus, severe coagulation disorders and severe cardiac diseases.
  • Known or suspected neurogenic bladder.
  • Urethral stricture or urethral cancer.

Treatment and study plan

bTURP

Procedure

transurethral resection of the prostate by bipolar current

Other names: TURIS

BEEP

Procedure

endoscopic enucleation of the prostate by bipolar current

Other names: TUEP

Primary outcomes

  1. volume of residual prostatic adenoma

    Time frame: one month postoperative

    measurement of volume of residual prostatic adenoma post bipolar TURP and BEEP was done by pelvi-abdominal ultrasound

  2. change in international prostate symptoms score

    Time frame: pre-operative, one, three, six and twelve months postoperative

    The international prostate symptoms score is a patient-completed questionnaire for standardized assessment of lower urinary tract symptoms (LUTS). It includes seven questions that evaluate the following urinary symptoms:

    • Weak urinary stream (0 : 5)
    • Incomplete bladder emptying (0 : 5)
    • Straining during urination (0 : 5)
    • Intermittent urine flow (0 : 5)
    • Increased urinary frequency (0 : 5)
    • Urgency (0 : 5)
    • Nocturia (0 : 5) Grade 1 (score = 0 - 7) : Mild LUTS Grade 2 (score = 8 - 19) : Moderate LUTS Grade 3 (score = 20 - 35) : Severe LUTS
  3. change in maximum urine flow rate(Q max)

    Time frame: pre-operative, 1, 3, 6 and 12 months postoperative

    Maximum urine flow rate was evaluated by Uroflowmetry

Secondary outcomes

  1. change in post voiding residual urine

    Time frame: pre-operative, 1, 3, 6 and 12 months postoperative

    post voiding residual urine in bladder was evaluated by Trans-abdominal ultrasound

  2. operation time

    Time frame: during operation

    Operation time was calculated from insertion of the cystoscope/resectoscope into the urethra to final removal of the scope

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

A Comparative Study Of Clinical Outcomes Of Bipolar Enucleation Of The Prostate Versus Bipolar TURP In Management Of Benign Prostatic Hyperplasia : A Randomized Controlled Clinical Trial

Acronym: TURP

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 21, 2026
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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