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Completed

NCT Number: NCT03949218

Bipolar Disorder and Oxidative Stress Injury Mechanism - Clinical Big Data Analysis Based on Machine Learning

This study is a single-center, retrospective, cross-sectional study. We plan to work with our network information center to analysis the related indicators of oxidative stress injury in patients with bipolar disorder based on oxidative stress data. During the study, machine learning was used as a data analysis method to screen out the biomarker risk factors with sensitivity and specificity for early recognition of bipolar disorder from major depression disorder with oxidative stress injury as the core. And then build up effective clinical predictive models for early identification of bipolar disorder, which can predict the early quantitative probabilistic of the onset of bipolar disorder.

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Key information

Conditions

Bipolar Disorder Bipolar and Related Disorders Mental Disorders Mood Disorders

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, 200030, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age is not limited
  • gender is not limited
  • meets the diagnostic criteria for bipolar disorder of ICD-10 F31,F32 and its sub-categories
  • has relevant HIS system data that can be utilized.

Exclusion criteria

  • patients who did not meet the appeal diagnosis after three-level rounds of ward
  • patients who met the above three diagnoses but had severe data loss (missing value ≥ estimated data value of 30%)

Treatment and study plan

Primary outcomes

  1. Early prediction model of bipolar disorder with oxidative stress index as the core

    Time frame: at August 2019

    Based on the oxidative stress data, the study will analysis related indicators of oxidative stress injury in patients with bipolar disorder. Then use the method of machine learning to build up the early prediction model of bipolar disorder.

Sponsors and collaborators

Lead sponsor

Shanghai Mental Health Center

Other

Registry information

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
May 14, 2019
Registry last updated
May 14, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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