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Recruiting

NCT Number: NCT05521503

Biopsy Collection and Repository Database

Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.

Recruiting

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Key information

Conditions

Cardiovascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

This is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.

Exclusion criteria

  • Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.

Treatment and study plan

Primary outcomes

  1. Discover and quantify the concentration of novel diagnostic and prognostic biomarkers

    Time frame: 12/21/2021-12/31/2030

    Use biospecimens procured from patients with cardiac conditions to identify diagnostic surrogate biomarkers using discovery proteomics. In Cardiac Amyloidosis, the serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established. The research aims to advance understanding of cardiac diseases and to support the development of improved therapies.

Study contacts

Contact information is provided by the study sponsor or research team.

Jennifer Isaacs, MS, MS

CONTACT

[email protected]

(859) 323-4738

Kenneth S Campbell, PhD

CONTACT

[email protected]

(859) 323-8157

Sponsors and collaborators

Lead sponsor

Kenneth S. Campbell

Other

Registry information

Official study title

Cardiac Biopsy Collection Repository and Database

Acronym: BICARD

Important dates

Study start
2021
Primary completion
2030
Study completion
2030
First posted
Aug 30, 2022
Registry last updated
Feb 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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