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Recruiting

NCT Number: NCT04388943

Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)

This project will examine the diagnosis and prognosis of patients with cardiovascular disease in hospital in- and outpatients and compare their characteristics with normal controls from the community. The cardiovascular diseases studied include coronary artery disease, heart failure, heart attacks, valve disease, cardiac surgery, dysrhythmias, aneurysms, embolism, strokes, peripheral vascular disease and hypertension. Current methods for diagnosis and predicting outcome in patients are limited and may lack accuracy. This study will collect clinical details, and blood and urine samples from patients for analysis of proteins, chemicals and genetic biomarkers which will enable an examination of the pathological mechanisms involved in cardiovascular disease. The data will also be used to improve diagnosis and also improve prediction of outcome in patients (future clinical events such as death, further hospitalisation with cardiovascular disease and the effects of any therapy given to the patients). In this way, we can develop accurate ways of assessing a patient's condition and how it could be effectively managed. The study will last for 20 years.

Recruiting

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Key information

Conditions

Cardiovascular Diseases Cardiovascular Risk Factor

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospitals Leicester

Leicester, United Kingdom

Location status: Recruiting

Location contact

Emma P Beeston

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All outpatients and inpatients with cardiovascular disease, of either gender
  • Aged 18-90 years old
  • Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain
  • Healthy volunteers
  • Aged 18-90 years old
  • From the community without cardiovascular or other diseases

Exclusion criteria

  • Any patient who is unable to give consent
  • Any patient with non-cardiovascular comorbidity likely to cause death within 6 months
  • Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material

Treatment and study plan

observation

Other

Physiological Measurements Patient reported questionnaire Blood sampling

Primary outcomes

  1. To improve understanding of disease mechanisms in cardiovascular disease

    Time frame: 20 Years

    The principal objective is to improve upon our understanding of disease mechanisms in cardiovascular disease, using plasma and urine proteins or chemicals and a patient's genetic makeup, which may impact on the diagnosis and assessment of prognosis of cardiovascular disease.

Secondary outcomes

  1. To improve prediction of responses to different treatments, using blood proteins or chemicals and a patient's genetic makeup

    Time frame: 20 Years

    Secondary objectives include predicting response to different treatments (which would include drugs, devices) using blood proteins or chemicals and a patient's genetic makeup, after appropriate matching by propensity scoring. Plus, assessing whether biomarkers in stool or other tissue can discern the presence and severity of coronary artery disease.

Study contacts

Contact information is provided by the study sponsor or research team.

Emma P Beeston

CONTACT

[email protected]

0116 204 4738

Tara Maitland

CONTACT

[email protected]

0116 204 4737

Sponsors and collaborators

Lead sponsor

University Hospitals, Leicester

Other

Collaborators

  • University of Leicester

Registry information

Important dates

Study start
2010
Primary completion
2027
Study completion
2027
First posted
May 14, 2020
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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