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OpenTrials
Completed

NCT Number: NCT03947346

Biomarkers of Renal Dysfunction in Neuroblastoma Survivors

The main purpose of this study is to learn more about biomarkers of kidney function in the blood and urine of neuroblastoma survivors. A biomarker is a biological molecule found in blood, urine, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition.

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Key information

Conditions

Neuroblastoma Survivors

Age range

Up to 20 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of neuroblastoma between 0-18 years of age
  • < 21 years of age at time of study enrollment
  • Two or more years from completion of systemic chemotherapy and/or radiation therapy

Exclusion criteria

  • Patients treated with observation only
  • Patients with multiple primary cancers

Treatment and study plan

Urine sample

Other

The urine collected from the first morning void will be used to assess urine creatinine and microalbumin. The fresh urine specimen will be analyzed for novel urinary biomarkers of (urinary NGAL, TGF-β1, IL-18 and KIM-1). Serum BUN, creatinine, and cystatin-C will be assessed using serum samples drawn for routine clinical care.

Primary outcomes

  1. indicators of renal injury

    Time frame: 2 years

    urine collected from the first morning void will be used to assess urine creatinine

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Important dates

Study start
2019
Primary completion
2025
Study completion
2025
First posted
May 13, 2019
Registry last updated
Jul 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.