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NCT Number: NCT04548362

Biomarkers of Meats and Potatoes Intake

This cross-over meal study is a four-way intervention with 12 volunteers randomized at the same time to four meals with fried meats (beef, pork, chicken and amino-acid matched non-meat control) and to four meals with potato products (boiled, chips, fries, and a control with boiled white rice) to search for biomarkers of intake.

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Key information

Conditions

Nutrition Disorders Nutritional and Metabolic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lars Dragsted

Frederiksberg, 1958, Denmark

About this study

In a two-dimensional, cross-over meal study, 12 healthy volunteers consumed in a randomized sequence four test meals: chicken, pork, beef, and a control made of egg white and pea. At the same time they were independently randomized to four starchy foods to be consumed together with the meats: boiled potatoes, fried potatoes, potato crisps or boiled white rice. Fasting and postprandial urine samples were collected to cover 48 h after each meal and samples were profiled by untargeted LC-ESI-qTOF-MS metabolomics. The profiles following the meal challenges were explored by univariate and multivariate analyses and single and combined markers of intake identified chemically by MS/MS fragmentation experiments and statistically by ROC curves and error rates as well as FDR statistics.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy

Exclusion criteria

  • non-pregnant, no abuse of alcohol or drugs, no chronic medication except p-pills

Treatment and study plan

Meat arm

Other

Randomised sequence of pork, beef, chicken meat, and an egg white/pea combination

Starchy foods arm

Other

Randomised sequence of boiled potato, fried potato, potato crisps, and boiled white rice

Primary outcomes

  1. meat intake biomarkers

    Time frame: 0-48 hours

    To identify intake biomarkers of general meat, red meat and poultry

  2. Potato intake biomarkers

    Time frame: 0-48 hours

    To identify intake biomarkers of general potato, fried potato and white rice

Sponsors and collaborators

Lead sponsor

Professor Lars Ove Dragsted

Other

Registry information

Official study title

Biomarkers of Meats and Potatoes Intake: a Meal Study in Healthy Men and Women - the MEPO Study

Acronym: MEPO

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Sep 14, 2020
Registry last updated
Apr 28, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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