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OpenTrials
Completed

NCT Number: NCT03056547

Biomarkers in Dyspnea

To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.

Completed

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Key information

Conditions

Healthy Volunteers

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre d'Investigation Clinique Paris Est - Groupe Hospitalier Pitié-Salpêtrière

Paris, 75013, France

About this study

The aim of the study will be to identify a specific biology and immunology associated with dyspnoea. It will open therapeutic possibilities through a better understanding of the mechanisms of dyspnea.

Healthy volunteers will underwent two types of dyspnea. The subjects will be first familiar with both types of dyspnea and dyspnea measurement scales. Different components of dyspnea will be measured.

Blood tests will be performed at different times (before dyspnea, during dyspnea, 60 and 90 min after dyspnea)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers

Exclusion criteria

  • pregnancy
  • ongoing pain
  • respiratory disease
  • high levels of depression, panic disorder, or other significant mental health problems
  • not fluent in french

Treatment and study plan

Induced dyspnea

Other

Biological samples will be assessed during and after breathing discomfort induced by laboratory models of dyspnea ("work/effort", "air hunger").

Primary outcomes

  1. Biomakers in dyspnea

    Time frame: 60 minutes

    Biomarkers in human model of induced dyspnea

Secondary outcomes

  1. Correlation with dyspnea intensity

    Time frame: 60 minutes

    Correlation between intensity of dyspnea and biomarkers

  2. Correlation with dyspnea type

    Time frame: 60 minutes

    Correlation between type of dyspnea and biomarkers

Sponsors and collaborators

Lead sponsor

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Other

Registry information

Acronym: BIODYSPNEE

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Feb 17, 2017
Registry last updated
Sep 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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