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OpenTrials
Completed

NCT Number: NCT02909998

Biomarkers in Chronic Arthritis

Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.

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Key information

Conditions

Chronic Arthritis

Age range

3 month and older

Sex eligibility

All sexes

Study type

Observational

About this study

Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients treated with biotherapy may be included in this study with all information necessary for regular medical consultations (filling specific monitoring by GPs questionnaires), physical therapists visits, occupational therapists, psychologists.. etc

Exclusion criteria

  • Patients treated with biological therapy for non rheumatic disease
  • Other inflammatory diseases such as Crohn's disease
  • Refusal to participate in the collection

Treatment and study plan

blood sample

Other

Conservation at the end of the blood sample

Primary outcomes

  1. Proportion of responsive patients with a given polymorphism (%)

    Time frame: At the inclusion

Secondary outcomes

  1. Distribution of patients with a given biotherapy (%)

    Time frame: At the inclusion

  2. Distribution of patients presenting a given polymorphism (%)

    Time frame: At the inclusion

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Evaluation of Predictive Genetic Markers of Response to Biologic Therapies in Chronic Arthritis

Important dates

Study start
2008
Primary completion
2014
Study completion
2014
First posted
Sep 21, 2016
Registry last updated
Sep 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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