Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients

Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Università di Parma

Parma, 43126, Italy

About this study

Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

symptomatic congestive heart failure lasting at least six months
reduced exercise tolerance
impaired or preserved left ventricular ejection fraction
cardiomegaly

Exclusion criteria

acute infection
rheumatoid or other autoimmune diseases
primary cachectic states (cancer, thyroid disease, severe liver disease)
severe chronic lung disease
neuromuscular disorders
myocardial infarction within the previous 20 weeks
diabetes mellitus
chronic renal failure (serum creatinine level > 2.0 mg/dl, >177 micromol/L)

Sponsors and collaborators

Lead sponsor

University of Parma

Other

Registry information

Official study title

Circulating Biomarkers as Prognostic Indicators of Death in Ambulatory Heart Failure Patients

Important dates

Study start: 1998
Primary completion: 2003
Study completion: 2009
First posted: Apr 30, 2010
Registry last updated: May 4, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed