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OpenTrials
Completed

NCT Number: NCT03343028

Biomarker Establishment for Superior Treatment of PTSD

The purpose of Biomarker Establishment for Superior Treatment of PTSD is to accelerate research on the discovery of biological, neurological and neuroimaging markers for Post- Traumatic Stress Disorder (PTSD). The investigators hope to validate and extend the network efficiency and verbal memory biomarker for PTSD. The investigators hope to learn whether there are pretreatment biological factors that can predict response to therapy. They want to do this by understanding the brain network function, relating EEG to functional magnetic resonance imaging, and application of network analysis tool.

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Key information

Conditions

PTSD Behavior Behavioral Symptoms Depression Mental Disorders Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

VA Palo Alto Health Care System (VAPAHCS), Palo Alto, California, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of PTSD by VA clinicians and acceptance into PE or CPT treatment as part of the PCT
  • Veterans of any era

Exclusion criteria

  • MRI safety contraindications
  • Active, uncontrolled medical illness
  • Acute suicidality
  • Current substance dependence
  • Current use of thyroid medication or active hyper/hypothyroidism
  • Neurological disorder affecting the CNS Seg stroke, epilepsy, tumorW or penetrating head injury
  • Use of PRN within 48 hours of the MRI/EEG

Treatment and study plan

Psychotherapy

Other

Other names: Cognitive Processing Therapy, Prolonged Exposure

Primary outcomes

  1. Understanding the brain network function-neuroimaging and behavioral with Clinician-Administered PTSD Scale for DSM-5

    Time frame: Approximately 3 months

    We will be using CAPS 5

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • New Mexico VA Healthcare System

Registry information

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Nov 17, 2017
Registry last updated
Feb 12, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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