Biomarker Analysis in Post-COVID Patients

Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system. We investigate cpost-COVID-19 patients with persistent headache lasting longer than 3 weeks, to hospitalized acute COVID-19 patients with neurological symptoms and to other non-COVID-19 disease-controls. Readout are neurologial and glial biomarkers in CSF.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Post-COVID-19 Syndrome COVID-19 Chronic Disease Coronaviridae Infections Coronavirus Infections Disease Attributes Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Acute COVID-19 Syndrome Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Laura de Boni

Bonn, 53105, Germany

About this study

Measurements of neuronal and glial markers in CSF were performed on a SIMOA analyzer (Quanterix) using the Neurology 4-Plex A (Nf-L, Tau, GFAP, UCH-L1) kit.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of COVID, Parkinson's disease, primary headache, Multiples Sclerosis, facial paralysis
Persistent post-COVID-19 headache after 3 months of infection
Post COVID-patients without persistent headache
must be able to perform lumbar puncture

Exclusion criteria

unknown history of COVID infection
lumbar puncture not possible

Treatment and study plan

No intervention

Other

no intervention

Primary outcomes

Biomarker analysis in CSF

Time frame: after 3 months of initial infection

Levels of Nf-L, Tau, GFAP, UCH-L1 in CSF

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Biomarker Analysis in COVID and Post-COVID Patients

Important dates

Study start: 2020
Primary completion: 2023
Study completion: 2023
First posted: May 1, 2023
Registry last updated: May 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed