Biological Markers Predicting Exercise Capacity in CF-LVAD Patients.

Establishing the association between biological markers and exercise capacity in continuous-flow left ventricular assist device patients.

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Key information

Conditions

Heart Failure Behavior Cardiovascular Diseases Heart Diseases Motor Activity

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Rigshospitalet.

Copenhagen, Kbh Oe, 2100, Denmark

About this study

The aim of this study is to investigate if specific biological markers can predict exercise capacity in advanced heart failure patients supported with continuous-flow left ventricular assist device patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Stable CF-LVAD patients.

Exclusion criteria

Unstable CF-LVAD patients.

Treatment and study plan

Primary outcomes

Biological markers

Time frame: Blood sampling on study day and samples are subsequently stored frozen.

Analysis of blood will be carried out on all samples simultaneously, expected markers are pro-BNP, MRproANP, copeptin, Gal-3 and proADM.

Secondary outcomes

Exercise capacity

Time frame: Examination on study day. Patients will only be followed on the day of the study. Exercise testing is performed as the last intervention on the study day.

Exercise capacity will be estimated by peak VO2 measurements on a upright ergometer bike with breath-by-breath gas analysis.

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Official study title

Biological Markers Predicting Exercise Capacity in Heart Failure Patients Supported With a Continuous-flow Left Ventricular Assist Device.

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Nov 27, 2014
Registry last updated: Oct 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed