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OpenTrials
Completed

NCT Number: NCT06776484

Biological Evolution of Whipple's Disease (WHIP)

Whipple's disease (WD), a rare systemic infection by Tropheryma whipplei, lacks research on biological abnormalities pre- and post-treatment. This study explores these abnormalities for their diagnostic and monitoring value.

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Key information

Conditions

Whipple Disease Actinomycetales Infections Actinomycosis Bacterial Infections Bacterial Infections and Mycoses Digestive System Diseases Gastrointestinal Diseases Gram-Positive Bacterial Infections Infections Intestinal Diseases Malabsorption Syndromes Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Brest

Brest, 29609, France

About this study

Whipple's disease (WD) is a rare systemic infection caused by *Tropheryma whipplei*. Despite advancements in diagnosis through PCR and biopsy, there is limited research comparing biological abnormalities before and after treatment. This study aimed to characterize these abnormalities and evaluate their potential for aiding in diagnosis and monitoring.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with at least one positive PCR test for Whipple's disease and a retained diagnosis at Brest University Hospital between 2010 and 2024
  • Major patient

Exclusion criteria

  • Minors
  • No screening test for Whipple's disease
  • Opposition to participation
  • Protected patients

Treatment and study plan

Primary outcomes

  1. Biological changes

    Time frame: 1 day

    Biological changes (inflammation, liver function tests, haematology, lymphocyte subpopulations) in patients diagnosed with classic, localised or reactive Whipple's disease

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Biological Evolution of Whipple's Disease

Acronym: WHIP

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jan 15, 2025
Registry last updated
Jan 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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