Recruiting

NCT Number: NCT04427462

Bioenergetic Phenotypes and Cardiometabolic Health

This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells. These small mitochondria inside the cells make energy, and are very important for the health of the body.

Recruiting

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Key information

Conditions

Healthy

Age range

8 year–10 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Arkansas Children's Nutrition Center

Little Rock, Arkansas, 72203, United States

Location status: Recruiting

Location contact

Tonja Nolen, MS

CONTACT

[email protected]

501-364-2853

About this study

Determine the impact of physical activity and obesity status on circulating cells mitochondrial function (e.g., fat vs. carbohydrates combustion capacity, total oxidative capacity, mitochondrial number and proton leak).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ages 8-10 years Boys and girls All ethnicity All BMI

Exclusion criteria

severe persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder

Opposition defiant disorder
conduct disorder
epilepsy
chronic kidney disease
hormonal disease
autoimmune diseases
bleeding disorders
chronic infections
mental health disorder
Type 2 and Type 1 diabetes
Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest

Treatment and study plan

Primary outcomes

Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.

Time frame: 8 days

Platelet mitochondrial respiration from isolated platelets will be measured using a flux analyzer. Adiposity will be measured with dual X-ray absorptiometry, and peak aerobic capacity with an incremental cycle ergometer test. measure physical activity

Study contacts

Contact information is provided by the study sponsor or research team.

Audrey Martinez, MS, RD, LD

CONTACT

[email protected]

501-364-3309

Tonja C Nolen, MS

CONTACT

[email protected]

501-364-3309

Sponsors and collaborators

Lead sponsor

Arkansas Children's Hospital Research Institute

Other

Registry information

Official study title

Linking Bioenergetic Phenotypes in Circulating Cells with Cardiometabolic Health in School-age Children

Acronym: MI Energy

Important dates

Study start: 2020
Primary completion: 2025
Study completion: 2026
First posted: Jun 11, 2020
Registry last updated: Feb 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting