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Completed

NCT Number: NCT03009942

Biochemical Mediators After Implant Loading

This study evaluates the nitric oxide and arginase levels in patients with dental implants. Peri-implant sulcular fluid and saliva samples were collected after loading of the implants

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Key information

Conditions

Implant Loading

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

About this study

Nitric oxide (NO) metabolism is associated with the clinical inflammatory state of peri-implant tissues and also affected by the mechanic stimulus. Therefore, The NO content of PISF reflects two different measures and can serve as an indicator of peri-implant soft tissue inflammation and/or bone response to force application and loading Arginase may reduce NO production by depleting the common substrate. Thus, increased salivary arginase activities detected in periodontitis patients may cause decreased NO synthesis and lead to a decrease in the antibacterial property of saliva.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with ≥ 20 teeth, no systemic diseases that could affect bone metabolism, no smoking habits, and had one or more implants

Treatment and study plan

Primary outcomes

  1. Biochemical parameters (nitric oxide and arginase) in periimplant sulcular fluid and saliva

    Time frame: Baseline and 1, 3 and 6 months after implant loading

    The changes in nitric oxide and arginase levels after implant loading were determined.

Secondary outcomes

  1. Plaque index

    Time frame: Baseline and 1, 3 and 6 months after implant loading

    The changes in plaque index after implant loading. Plaque index was recorded for determining and classifying oral hygiene status.

  2. Gingival index

    Time frame: Baseline and 1, 3 and 6 months after implant loading

    The changes in gingival index after implant loading. Gingival index was recorded for classifying and evaluating gingival inflammation.

  3. Probing depth

    Time frame: Baseline and 1, 3 and 6 months after implant loading

    The changes in probing pocket depth after implant loading.Probing pocket depth was measured for determining periimplant health.

  4. Bleeding on probing

    Time frame: Baseline and 1, 3 and 6 months after implant loading

    The changes in bleeding on probing after implant loading. Bleeding on probing was recorded for evaluating gingival inflammation.

Sponsors and collaborators

Lead sponsor

Gazi University

Other

Registry information

Official study title

Nitric Oxide and Arginase Levels in Peri-Implant Tissues After Delayed Loading

Important dates

Study start
2010
Primary completion
2011
Study completion
2012
First posted
Jan 4, 2017
Registry last updated
Jan 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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