Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms

Primary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), cancer-related symptoms (pain, depression, anxiety, fatigue and sleep disturbance), and genetic factors (APOE, COMT, BDNF) associated with the level of subjective or the level of objective cognitive dysfunction in breast cancer and colorectal cancer survivors.

Secondary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), and genetic factors (APOE, COMT, BDNF) associated with psychoneurological symptom cluster using either subjective or objective cognitive dysfunction in breast cancer and colorectal cancer survivors.

Inclusion criteria

Inclusion criteria

for Breast cancer survivors:

• Female BCS
• ≥ 21 years of age and older
• Ability to provide written consent and HIPAA authorization
• ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (Stage I-IIIA) breast cancer.

Current Aromatase Inhibitors or Tamoxifen treatment at time of enrollment is allowed.

• Identify cognitive concerns (select yes)

Inclusion criteria

for Colorectal cancer survivors:

• Male or female CRC survivors
• Ability to provide written consent and HIPAA authorization
• ≥ 21 years of age and older
• ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (stage I-III) CRC
• Identify cognitive concerns (select yes)

Exclusion criteria

• Report metastatic breast or colorectal cancer (Stage IV) at time of consenting.
• Unable to read and understand English to complete survey questionnaires.