Bioavailabity of the Major Metabolites of a Botanical Extract, in Healthy Adults

Inclusion criteria

• Male adults
• Age between 18 and 35 years (limits included);
• Non-smoking individuals (nor tobacco, nor electronic cigarette nor cannabis, former smokers can be included if they stopped smoking at least 2 years ago);
• Body Mass Index ≥ 19 and < 30 kg/m2.
• Considered healthy based on their medical history, clinical examination and biological examination;
• Subjects capable of and willing to comply with the protocol and to give their written informed consent.
• Subjects affiliated with a social security scheme.

Non-inclusion Criteria:

Subjects complying with at least one of the following criteria will not be eligible:

• Known metabolic abnormality or clinically significant medical condition, such as:

• Cardiovascular disease (other than hypertension),
• Neurological disease,
• Psychatric disease,
• Immunological disease,
• Endocrine disease (including diabetes or thyroid diseases),
• Chronic kidney disease,
• Heamatological abnormalities
• Hypertension (SBP≥160 mm Hg or DBP ≥100 mm Hg).
• Use of any type of medication or narcotic drug (detected either by the self-declaration of the participant and/ or by the urine TetraHydroCannabinol (THC) test) currently or within the past 2 months before entry into the study;
• Self-reported alcohol intake of >10 units/ week
• Weight changes above 10% body weight within the past 6 months before entering the study;
• Currently under prescribed diet regimen, whatever the reason;
• Consumption of food supplement(s) currently or within the past 4 weeks before entry into the study, such as but not limited to: botanicals, vitamins, minerals, amino acids; anti-oxydant;
• Any intolerance or allergy documented or suspected to one of the components of the study products;
• Subject presenting a psychological or linguistic inability to sign the informed consent;
• Subject under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision;
• Subject participating in another biomedical study or participation in another study where a product (ie: dietary supplement) were consumed within the 3 months before entry into this study;
• Any regulatory reason according to national applicable regulation;
• Subject having received indemnities for clinical trial reaching at least 4500 Euros considering the last 12 months.

Exclusion criteria

During the study, in case of emergence of a new health condition or treatment considered as non-inclusion criteria or likely to affect the study parameters according to Investigator's judgment, the participants will be excluded from the study