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Completed

NCT Number: NCT01881295

Bioavailability of Potassium From Potatoes and Potassium Gluconate

This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.

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Key information

Conditions

Potassium Bioavailability Blood Pressure

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Purdue University

West Lafayette, Indiana, 47907, United States

About this study

The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg).

During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to adhere to the visit schedule, protocol requirements and available to complete the study
  • Normotensive men and women
  • Aged 20-60 years
  • BMI of 15-35

Exclusion criteria

  • Medication to treat hypertension or hypotension
  • Medication known to affect electrolyte metabolism or contain high levels of potassium or sodium
  • smoke cigarettes or use illegal drugs
  • Hypertension or hypotension
  • Diseases known to affect potassium metabolism
  • Pregnant
  • Allergic to nuts

Treatment and study plan

Placebo Control

Dietary Supplement

Low dose potassium gluconate

Dietary Supplement

Medium dose potassium gluconate

Dietary Supplement

High dose potassium gluconate

Dietary Supplement

Low dose potato

Dietary Supplement

Medium dose potato

Dietary Supplement

High dose potato

Dietary Supplement

High dose French fries

Dietary Supplement

Basal diet control

Dietary Supplement

Primary outcomes

  1. Bioavailability of Potassium

    Time frame: 5 days

    After 4 days of acclimation to the supplementation, absorption of potassium will be measured.

Secondary outcomes

  1. Blood Pressure Response to Potassium

    Time frame: 6 days

    Differences in blood pressure will be measured between levels of potassium consumption.

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Collaborators

  • Alliance for Potato Research and Education

Registry information

Acronym: Potato

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jun 19, 2013
Registry last updated
May 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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