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OpenTrials
Completed

NCT Number: NCT04872530

Bioavailability of Plant Protein Amino Acids

This study aims to inform of the mechanism of action of plant-based protein by measuring the bioavailability (i.e. rate of appearance and magnitude of concentration in the circulation following oral ingestion) of key amino acid and metabolic products that regulate skeletal muscle protein synthesis (MPS) in humans.

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Key information

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Education and Health Sciences

Limerick, V94 T9PX, Ireland

About this study

Plant-based proteins contain several amino acids that are essential to signal muscle growth/repair and act as a substrate during muscle protein synthesis. However, compared to animal protein or free-amino acids, the bioavailability of certain essential amino acids may be compromised. Following selective processing (e.g. removal of carbohydrate and/or other anti-nutritive factors) food grade plant-based protein concentrates possibly confer greater bioavailability and bioactivity in vivo. This project explores the bioavailability and bioactivity of selected plant-based protein concentrates following oral ingestion in young, healthy men and women.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No known intolerance to any item contained in the protein products.
  • No blood borne disease risk, current illness or medication that would adversely affect participation
  • No known adverse reaction to venepuncture

Exclusion criteria

  • n/a

Treatment and study plan

Pea-protein concentrate

Dietary Supplement

Pea-protein concentrate

Fava-bean protein concentrate

Dietary Supplement

Fava-bean protein concentrate

Chickpea protein concentrate

Dietary Supplement

Chickpea protein concentrate

Red lentil protein concentrate

Dietary Supplement

Red lentil protein concentrate

Non-essential amino acid blend

Dietary Supplement

Non-essential amino acid blend

Whey Protein Concentrate

Dietary Supplement

Whey protein concentrate

Primary outcomes

  1. Plasma amino acids

    Time frame: 3 hours

    Plasma amino acids measured by HPLC

Sponsors and collaborators

Lead sponsor

University of Limerick

Other

Collaborators

  • Enterprise Ireland
  • Marigot Ltd.

Registry information

Official study title

Bioavailability of Amino Acids and Metabolic Products Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men and Women Aged 18-35y

Important dates

Study start
2020
Primary completion
2021
Study completion
2023
First posted
May 4, 2021
Registry last updated
Nov 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.