Bioavailability of EPA + DHA in a SMEDS Formulation

Inclusion criteria

• Body mass index 18.50-29.99 kg/m2
• Good health on basis of medical history and routine laboratory tests
• Score of at least 7 on vein access scale
• Willing and able to remain at site for extended testing periods, including a total of 4 overnight stays, and to consume foods and products provided by study staff on those days
• Willing to abstain from alcohol for 24 h prior to clinic admission
• No plans to change smoking habits or other nicotine use
• Willing to undergo 13 venipunctures during each treatment period

Exclusion criteria

• Screening lab test of clinical significance
• Positive urine drug screen
• Clinically significant endocrine, cardiovascular, renal, hepatic, pulmonary, pancreatic, neurologic, gastrointestinal or biliary disorder
• Uncontrolled hypertension
• Recent history or presence of cancer
• Difficulty swallowing capsules
• Recent blood donation or blood loss
• Recent consumption of high-dose fish oil or fish
• Recent use of any prescribed medication or over-the-counter medicinal products, including herbal or dietary supplements (except daily omega-3 fatty acid-free vitamin and/or mineral supplement or occasional use of acetaminophen or non-steroidal anti-inflammatory drugs)
• Signs or symptoms of active infection or has recently taken antibiotics
• Recent history or strong potential for drug or alcohol abuse
• Pregnant, planning to be pregnant during the study, lactating or of childbearing potential and unwilling to commit to use of a medically approved form of contraception throughout the study (note: hormonal contraceptive use is not allowed)