Bioavailability and Metabolism of Avenanthramide: a Novel Oat Phytochemical

Inclusion criteria

• Male and female non-obese subjects (18kg/M2<BMI<28kg/M2)
• Age 20-45 years)
• Sign an informed consent form approved by UMN-IRB
• Willing to avoid oat consumption and rigorous physical activity the day prior to and through test, and consume a low-flavonoid diet for 1 week prior to the study

Exclusion criteria

• Presence of GI conditions that interfere with absorption;
• Clinically significant endocrine, cardiovascular, pulmonary, renal, hepatic, pancreatic, biliary or neurologic disorders;
• Major trauma or surgery within 3 months of visit;
• Cancer in the prior 2 years;
• Allergic to oat products;
• Women who are pregnant or lactating;
• Smoking;
• Drinking alcohol >5 drinks/week;
• Using nutraceuticals;
• Blood pressure medication;
• NSAID (>800 mg ibuprofen/week);
• Vitamin supplementation;
• Anticoagulants or hypoglycemic drugs;
• Oat products consumption the day before the test;
• Rigorous physical activity the day before the test;
• Consumption of a high-flavonoid diet in the week prior to the test.