Bingo Drug-eluting Balloon in Bifurcation

Inclusion criteria

• Male or non-pregnant female ages 18-80 years old
• Patients with asymptomatic myocardial ischemia symptom, stable or unstable angina pectoris or old myocardial infarction
• Patients with bifurcation lesions of coronary artery observed by angiography.
• The main branch of the vessels are suitable for PCI and stent therapy, and the side branch are intended to implement the kissing dilatation without considering dual stent implantation.
• De Novo bifurcation lesions and diameter stenosis are not less than70%;
• Referenced vessel diameters range from 1.25mm to 5.0mm, and lesions range are not more than 40mm
• Residual stenosis are not more than 50% after predilatation;
• Patients who understand the purpose of this trial, voluntary and sign informed consent.

Exclusion criteria

• Heavily calcified lesions which cannot be dalatated successfully, and the lesions which are not suitable by balloon angioplasty
• Left main coronary artery lesions without protection or related bifurcation lesions
• Patients with severe heart failure symptoms (above NYHA III) or Left ventricular ejection fraction (LVEF) below 35% (ultrasound or left ventricular angiography)
• Impairment of the renal function preoperative: Serum creatinine above 2.0mg/dl；
• Patients with hemorrhagic tendency, the history of active digestive ulcers, the history of subarachnoid hemorrhage cerebral hemorrhage, antiplatelet and anticoagulant therapy contraindication and unable to anticoagulant therapy;
• Patients who are allergic to aspirin, ticagrelor, clopidogrel, ticlopidine, heparin, contrast agent and paclitaxel, and cannot 1-year tolerate dual antiplatelet therapy (aspirin + clopidogrel or ticagrelor)
• Patients whose expected lives are less than 1 year;
• Patients who are considered to have poor compliance and cannot complete the trial in accordance with requirements.
• In-stent restenosis lesions
• Patients who are enrolled in this trial and need stent therapy due to vascular laceration or severe stenosis, and those patients are calculated as fall off cases.