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NCT Number: NCT07514403

Bilogical Assesment During Intrusion of Lower Incisors

biological assesment during intrusion of lower incisors

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Key information

Conditions

Orthodontic Treatment Efficiency

Age range

14 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Assessment of the biological response of the corticision during intrusion of lower incisors A prospective clinical study

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients requiring extraction-based orthodontic treatment
  • Presence of deep overbite requiring lower incisor intrusion
  • Age range: 18-30 years
  • Good general health
  • Good oral hygiene

Exclusion criteria

  • Systemic diseases affecting bone metabolism
  • Previous orthodontic treatment
  • Periodontal disease
  • Smoking
  • Pregnancy or lactation

Treatment and study plan

Corticision

Other
  • Prior panoramic x-ray or serial periapical x-rays are essential to assure the availability of interradicular room to carry out the procedure.
  • Preoperative antiseptic mouthwash is administered to prevent potential infections.
  • Infiltration anesthesia is applied.
  • A reinforced 15T scalpel is positioned on the interradicular attached gingiva at an inclination of 45-60 degrees on the long axis of the tooth to be moved.

Primary outcomes

  1. Gingival crevicular fluid (GCF) prostaglandin E2 (PGE2) levels measured by enzyme-linked immunosorbent assay (ELISA) (pg/mL)

    Time frame: 12 weeks

    GCF samples will be collected from lower incisors using microcapillary tubes at baseline and during follow-up visits. Prostaglandin E2 levels will be quantified using ELISA kits and expressed in pg/mL to assess the biological response to corticision-assisted intrusion.

Secondary outcomes

  1. Amount of lower incisor intrusion measured in millimeters (mm) using cone beam computed tomography (CBCT)

    Time frame: 12 weeks

    CBCT imaging will be used to measure the vertical displacement of lower incisors in millimeters by comparing pre- and post-treatment positions.

  2. External apical root resorption measured in millimeters (mm) using cone beam computed tomography (CBCT)

    Time frame: Time Frame: 12 weeks

    CBCT imaging will be used to assess external apical root resorption by comparing root lengths before and after treatment.

Study contacts

Contact information is provided by the study sponsor or research team.

Mahmoud Fathy Aboelmahasen, lecturer

CONTACT

[email protected]

01222993381

alaa eldin elshahat shafay, post gradute student

CONTACT

[email protected]

+201016886788

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Assessment of the Biological Response of the Corticision During Intrusion of Lower Incisors A Prospective Clinical Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 7, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.