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OpenTrials
Completed

NCT Number: NCT06956638

Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation

The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation

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Key information

Conditions

Acute Appendicitis Appendicitis Appendicitis Perforated Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections

Age range

5 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Shree Birendra Hospital

Kathmandu, Bagmati, 44620, Nepal

About this study

The study aims to assess hyperbilirubinemia: serum direct, indirect and total bilirubin to enhance the diagnostic accuracy of acute appendicitis. Also it aims to analyze different patient variables such as age, gender, duration of symptoms, leukocyte and neutrophil count, Alvarado score, presence of fever, nausea & vomiting, peritonitis alongside serum total bilirubin level in patients with appendicitis and assess which variables can be taken as independent factors to predict appendiceal perforation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of age group above 5 years with acute appendicitis undergoing appendectomy with written informed consent.

Exclusion criteria

  • Patients with appendicular lump.
  • Patients with acute and chronic liver diseases like acute hepatitis, hemolytic disease, Gilbert's syndrome, Dubin-Johnson syndrome, alcoholic liver disease.
  • Acquired or Congenital Biliary Disease.
  • History of Hepatotoxic drugs.

Treatment and study plan

Non-Interventional

Other

Non-interventional study

Primary outcomes

  1. Perforated appendix

    Time frame: Presentation to hospital till perioperative period

    Perforated appendicitis was confirmed intraoperatively by the surgeon and at histological analysis of the specimen by the rupture of appendiceal wall to the serosa. Those with gangrenous walls were also taken as perforated.

Sponsors and collaborators

Lead sponsor

Nepalese Army Institute of Health Sciences

Other

Registry information

Official study title

Predictors of Appendiceal Perforation and the Role of Total Bilirubin at Presentation: A Single Center Prospective Cross-sectional Study in Nepal

Important dates

Study start
2022
Primary completion
2023
Study completion
2025
First posted
May 4, 2025
Registry last updated
May 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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