Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects

PURPOSE

The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.

In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.

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Key information

Conditions

Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Gentofte University Hospital

Hellerup, 2900, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Healthy)

Normal fasting plasma glucose
Normal glucose tolerance
Normal haemoglobin levels
Informed content

Inclusion criteria

(cholecystectomy group)

Laparoscopic cholecystectomy <6 months. Indication: Gallstones.
Normal fasting plasma glucose
Normal glucose tolerance
Normal haemoglobin levels
Informed content

Exclusion criteria

(both groups)

Diabetes
Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
1st degree relatives with diabetes
Obesity (BMI > 30)
Inflammatory bowels disease
Nephropathy
Liver disease
Medication which cannot be on hold for 24h

Treatment and study plan

Primary outcomes

GLP-1 secretion

Time frame: Postprandial

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Dec 2, 2010
Registry last updated: Jan 23, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed