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NCT Number: NCT07738900

Bilateral Modified Thoracoabdominal Nerve Block as an Analgesic Technique in Comparison With Bilateral Thoracic Erector Spinae Plane Block in Abdominoplasty Operations

This study aimed to compare the analgesic effect of bilateral ultrasound-guided modified thoracoabdominal nerve block with bilateral ultrasound-guided erector spinae plane block in abdominoplasty surgery.

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Key information

Conditions

Modified Thoracoabdominal Nerve Block (M-TAPA) Abdominoplasty Analgesic Technique Thoracic Erector Spinae Plane Block

Age range

21 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura University

Al Mansurah, Dakahlia Governorate, 35516, Egypt

About this study

Abdominoplasty is an extra-peritoneal surgery devoid of visceroperitoneal component of pain, most of pain is initially related to the abdominal wall's facial plication in addition to pain generated from the abdominal wall incision.

Ultrasound guided erector spinae plane block (ESPB) is considered relative an effective block that can be used to provide postoperative analgesia in abdominoplasty (Tulgar et al., 2018). Erector spinae plane block (ESPB) is an interfascial plane block was used to relieve chest neuropathic pain.

The modified thoracoabdominal nerve block through the perichondral approach (M-TAPA) is a novel regional nerve block that can provide optimal analgesia for both the lateral and anterior abdominal wall. It can provide wide range of analgesic coverage of the trunk (i.e., T7-T12) by a single puncture per side and has been initially reported to provide a longacting analgesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 21 and 60 years.
  • Both sexes.
  • American Society of Anesthesiologists physical status grade I and grade II.
  • Elective abdominoplasty operation.

Exclusion criteria

  • Patient refusal.
  • Local skin infection and sepsis at site of the block.
  • Known allergy to local anesthetic drugs.
  • Coagulopathy.
  • Psychiatric diseases.
  • Central or peripheral neurological disease.

Treatment and study plan

General Anaesthesia using intravenous propofol, fentanyl intravenous, and atracurium besylate

Drug

Patients received only standard general anesthesia using intravenous propofol (2-3 mg/kg), fentanyl intravenous (1.5µ/kg) and atracurium besylate (0.6 mg/kg).

Modified thoracoabdominal nerve block using 25 mL of bupivacaine 0.25%

Drug

Patients received modified thoracoabdominal nerve block bilaterally using 25 mL of bupivacaine 0.25% and a lidocaine mixture (15 mL of bupivacaine 0.5% plus 5 mL of 2% lidocaine).

Erector spinae plane block using 25 mL of bupivacaine 0.25%

Drug

Patients receive erector spinae plane block bilaterally using 25 mL of bupivacaine 0.25% and a lidocaine mixture (15 mL of bupivacaine 0.5% plus 5 mL of 2% lidocaine).

Primary outcomes

  1. Total opioid consumption

    Time frame: 24 hours postoperatively

    Intravenous pethidine (0.5mg/kg) was taken every 12 hours as rescue analgesia.

Secondary outcomes

  1. Duration of analgesia

    Time frame: 24 hours postoperatively

    Duration of analgesia was recorded from the end of surgery till the first dose of pethidine administered.

  2. Degree of pain

    Time frame: 24 hours postoperatively

    A postoperative numeric rating scale (NRS) was employed to assess patients' postoperative pain levels. It is scored from 0 to 10 (0 meaning no pain and 10 meaning the worst pain). NRS was assessed at 0, 6, 12, and 24 hr postoperative.

  3. Cortisol level

    Time frame: 24 hours postoperatively

    Cortisol level was recorded at basal, 8 hr, and 24 hr postoperative.

  4. C-reactive protein (CRP) level

    Time frame: 24 hours postoperatively

    The C-reactive protein (CRP) level was recorded at basal, 8 hr, and 24 hr postoperatively.

  5. Incidence of complications

    Time frame: 24 hours postoperatively

    Incidence of complications such as nausea, vomiting, pruritus, and respiratory depression were recorded.

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Efficacy of Bilateral Modified Thoracoabdominal Nerve Block as an Analgesic Technique in Comparison With Bilateral Thoracic Erector Spinae Plane Block in Abdominoplasty Operations

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 31, 2026
Registry last updated
Jul 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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