Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure

This study constitutes a bidirectional cohort investigation. By collating laboratory parameters and clinical data-including plasma and peripheral blood mononuclear cell (PBMC) analyses-from patients with acute-on-chronic liver failure, it aims to provide a reference framework for predicting prognosis and the occurrence of complications.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Liver Failure Digestive System Diseases Hepatic Insufficiency Liver Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University

Chongqing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

•Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF)

Exclusion criteria

age < 18 years
extrahepatic organ failure unrelated to ACLF
active malignancy
co-infection with other hepatitis viruses or human immunodeficiency virus (HIV)
prior liver transplantation
use of immunosuppressants within 6 months before enrollment
unclear history of antiviral therapy

Treatment and study plan

Primary outcomes

Primary endpoint was all-cause mortality at days 28, 90, 180, and 360.

Time frame: Days 28, 90, 180, and 360

Sponsors and collaborators

Lead sponsor

The Second Affiliated Hospital of Chongqing Medical University

Other

Registry information

Official study title

Bidirectional Cohort Study on Prognostic Model Construction for Acute-on-Chronic Liver Failure

Important dates

Study start: 2018
Primary completion: 2026
Study completion: 2026
First posted: Apr 23, 2026
Registry last updated: Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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