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NCT Number: NCT06918704

BID WM Digital Intervention in Aging

The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are:

1. Does engagement in with a digital intervention improve working memory? 2. Does engagement in with a digital intervention improve inhibitory control?

Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.

Participants will conduct study activities remotely (e.g., at-home):

1. Baseline Assessment. Complete a series of cognitive assessments and surveys. 2. Intervention. Engage in a digital intervention for up to 8 weeks. 3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment. 4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

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Key information

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California, San Francisco

San Francisco, California, 94621, United States

Location status: Recruiting

About this study

During the Baseline Assessment, participants will complete web-based cognitive assessments and surveys. The assessments will address various cognitive functions including working memory, long-term memory, inhibitory control, and sustained attention. Surveys will include a characterization of expectancy for the intervention, ratings of stress, and background health information. The Baseline Assessment will take up to 120 minutes and can be completed across more than one session.

During the Intervention, participants will be provided an iPad tablet to engage with the assigned intervention app. Participants will be randomly assigned to one of two intervention apps. Regardless of the assigned intervention, participants will engage with the app for 25-45 minutes of training per day, 5 days a week for up to 8 weeks for a total of 1000 minutes of training.

After the intervention, participants will complete a Post Intervention Assessment and 6 month later, a Follow-Up Assessment. Both of these assessment periods will consist of the same cognitive assessments and surveys as conducted during the Baseline Assessment.

Upon completion of all study activities, participants will be able to keep the iPad as a gift for their voluntary participation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Minimum of 12 years of education
  • English fluency
  • Normal or corrected-to-normal vision
  • Normal or corrected-to-normal vision
  • Medically healthy older adults including those with below-average cognitive performance or mild cognitive impairment patients without dementia

Exclusion criteria

  • Under the age of 60
  • Clinical diagnosis of neurological or psychiatric disorder
  • Visually or hearing impaired without correction to normal
  • Clinical diagnosis of dementia or AD8 score of >3
  • Regularly (one or more times per week) practicing an instrument within the last year
  • 10 or more years of formal musical instrument training

Treatment and study plan

Coherence

Behavioral

Coherence is a music-based rhythm training app.

Worder

Behavioral

Worder is a word search app.

Primary outcomes

  1. Working Memory

    Time frame: Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

    Working memory performance will be assessed with a delayed match-to-sample task.

Secondary outcomes

  1. Inhibitory Control

    Time frame: Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

    Inhibitory control will be assessed with the Stroop task.

  2. Inhibitory Control

    Time frame: Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

    Inhibitory control performance will be assessed by distractors within a delayed match-to-sample task.

Study contacts

Contact information is provided by the study sponsor or research team.

Melissa Arioli

CONTACT

[email protected]

(415) 506-7321

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Official study title

Behavioral Intervention Development Core - Working Memory Digital Intervention in Aging

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Apr 9, 2025
Registry last updated
Apr 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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