Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit

The aim of this study is to compare bicarbonates versus saline for prevention of contrast induced acute kidney injury in critically ill patients.

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Key information

Conditions

Contrast Induced Acute Kidney Injury

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Medical Intensive Care Unit, Caen, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patient > 18 years old
in intensive care unit since 24h and for up to 48 hours
with contrast medium injection

Exclusion criteria

patient under renal replacement therapy
rise in creatinine > 26µmol/L within 48hours
anuria within 12 hours
cardiogenic pulmonary oedema
pH > 7.50 or kaliemia < 3mmol/L
pregnancy

Treatment and study plan

bicarbonates

Drug

sodium bicarbonates 1,4%

Saline

Drug

sodium chloride 0,9%

Primary outcomes

contrast induced acute kidney injury

Time frame: 72 hours

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Acronym: HYDRAREA

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Jul 10, 2012
Registry last updated: Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed