Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.

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Key information

Conditions

Cardiac Arrest Acid-Base Imbalance Acidosis Cardiovascular Diseases Heart Arrest Heart Diseases Metabolic Acidosis Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult cardiac arrest patient with arterial pH <7.1 or bicarbonate <10mmEq/L checked at 10 minutes of cardiopulmonary resuscitation

Exclusion criteria

age <18 trauma patient Do Not Resuscitate state

Treatment and study plan

Sodium bicarbonate

Drug

Administer Sodium bicarbonate 50 mEq IV over 2 minutes

Other names: Bivon

normal saline

Drug

Placebo

Other names: 0.9% sodium chloride

Primary outcomes

Return of Spontaneous Circulation (ROSC)

Time frame: checked during CPR, duration of ROSC >20 min

Percentage of Participants with Return of Spontaneous Circulation (ROSC)

Sponsors and collaborators

Lead sponsor

Asan Medical Center

Other

Registry information

Official study title

Pilot Study of Bicarbonate Injection for Improving Outcome in Patients With Out-of-hospital Cardiac Arrest, Double-blind Randomized Control Trial

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Dec 1, 2014
Registry last updated: Mar 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed