BFR and Muscle Mitochondrial Oxidative Capacity

Inclusion criteria

.

• Capable and willing to give written informed consent
• Capable of understanding inclusion and exclusion criteria
• 18-40 years of age inclusive
• Body Mass Index (BMI) between 18.5-30 kg/m2 inclusive
• No medical condition that would limit their participation in supervised exercise training based on the Physical Activity Readiness Questionnaire for Everyone (PARQ+)
• No current prescription medications, with the exception of birth control
• Willing to allow researchers to use data, biospecimens (e.g., blood) and images (e.g., Dual Energy x-Ray Absorptiometry) for research purposes after study participation is completed

Exclusion criteria

.

• Evidence or self-report being pregnant, lactating, or anticipating becoming pregnant in the next year
• Participation in resistance or aerobic exercise training > 2 days per week within the 3 months prior to screening
• Self-report of history of type 1 or 2 diabetes mellitus
• Self-report history of cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
• Self-report or evidence of uncontrolled hypertension
• Self-report history of blood clotting disorders
• Self-report history of deep vein thrombosis or pulmonary embolism
• Self-report history of sickle cell trait
• Self-report history of varicose veins
• Self-report history of a myopathy leading to muscle loss, weakness, severe cramps or myalgia
• Self-report history of orthopedic limitations that would preclude them from participation in a dynamic exercise program
• Self-report history of musculoskeletal disorders (e.g., severe osteoarthritis, rheumatoid arthritis, avascular necrosis or osteonecrosis)
• Self-report history of neurological disorders (e.g., peripheral neuropathy, amyotrophic lateral sclerosis, multiple sclerosis, fibromyalgia, Parkinson's disease)
• Weight loss of > 10% in the last 3 months prior to screening
• Active smoking
• Current consumption of > 14 alcoholic drinks per week based on self-report
• Absolute Contraindication to Exercise as Defined by the American College of Sports Medicine,1 including:

• Resting diastolic blood pressure > 100 mm Hg
• Resting systolic blood pressure > 180 mm Hg
• Resting heart rate > 100 beats per min
• Self-report acute viral or bacterial upper or lower respiratory infection at screening
• Any other condition that in the judgement of the Principal Investigator and/or the Medical Director of this protocol may interfere with study participation and adherence to the protocol