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NCT Number: NCT07507344

Beverage Hydration Index of Different Solutions

In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the Beverage Hydration Index above water alone and perform comparably to the carbohydrate rich solution.

This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.

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Key information

Conditions

Hydration

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Center for Nutraceutical and Dietary Supplement Research

Memphis, Tennessee, 38152, United States

Location status: Recruiting

Location contact

Jackie Pence, PhD

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Be age 18 years or older
  • male or female
  • have a body mass index (BMI)between 18.5-35 kg/m2 (not morbidly obese)
  • Be engaged in moderate physical activity, defined as ≤5 hours/week of aerobic exercise
  • Not have a history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder (reviewed by Nurse practitioner)
  • Not have other conditions that are likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status (as determined by Nurse practitioner)
  • Not be consuming any medication which may alter fluid retention/electrolyte levels such as Selective Serotonin Reuptake Inhibitors, sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium. (Medications will be reviewed by Nurse practitioner)
  • Not consume nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening.
  • Follow the lifestyle and dietary restrictions before study visits (excluding screening/consenting visit) including before each visit avoiding strenuous activity for 24 hours prior, refrain from caffeine for 12 hours and alcohol for 24 hours, consume the standardized diet and maintain similar activity levels for 24 hours prior, consume 2.5 liters for men or 2.0 liters for women day prior, and fast (water only) of at least 10 hours prior.
  • Not have a sensitivity or be allergic to any components of the study interventions (water, calcium chloride, magnesium chloride, potassium bicarbonate, magnesium, sodium, chloride, potassium, vitamin C, dextrose, AminoAbsorb (L-alanine, L-glutamine, glycine).
  • Not be a tobacco user
  • Not be following a specialized dietary pattern that may alter findings (e.g., low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting etc.)
  • Arrive to lab for visits euhydrated (USG 1.005-1.020)
  • Have the ability and willingness to fast (consume water/treatments only) for 15 hours (10 hours prior to lab visits not including screening)
  • Not be enrolled in another clinical study within 30 days of the first study visit
  • Be without active infection or illness of any kind
  • Not be pregnant or breastfeeding
  • Not have surgery in the previous 4 months

Treatment and study plan

Hydramin hydration solution

Dietary Supplement

4 sticks of electrolyte and amino acid powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, AminoAbsorb (L-glutamine, L-Alanine, Glycine)

Carbohydrate and Electrolyte hydration solution

Dietary Supplement

4 sticks of electrolyte and carbohydrate powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, Dextrose

Water

Dietary Supplement

1 L Smart Water

Primary outcomes

  1. Beverage Hydration Index

    Time frame: 0 minutes after beverage consumption

    Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment

  2. Beverage Hydration Index

    Time frame: 60 minutes after beverage consumption

    Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment

  3. Beverage Hydration Index

    Time frame: 120 minutes after beverage consumption

    Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment

  4. Beverage Hydration Index

    Time frame: 180 minutes after beverage consumption

    Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment

  5. Beverage Hydration Index

    Time frame: 240 minutes after beverage consumption

    Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment

  6. Net Fluid Balance

    Time frame: 0 minutes after beverage consumption

    Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed

  7. Net Fluid Balance

    Time frame: 60 minutes after beverage consumption

    Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed

  8. Net Fluid Balance

    Time frame: 120 minutes after beverage consumption

    Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed

  9. Net Fluid Balance

    Time frame: 180 minutes after beverage consumption

    Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed

  10. Net Fluid Balance

    Time frame: 240 minutes after beverage consumption

    Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed

  11. Urine Specific Gravity

    Time frame: 0 minutes before beverage consumption

    Urine Specific Gravity measured via refractometry.

  12. Urine Specific Gravity

    Time frame: 0 minutes after beverage consumption

    Urine Specific Gravity measured via refractometry.

  13. Urine Specific Gravity

    Time frame: 60 minutes after beverage consumption

    Urine Specific Gravity measured via refractometry.

  14. Urine Specific Gravity

    Time frame: 120 minutes after beverage consumption

    Urine Specific Gravity measured via refractometry.

  15. Urine Specific Gravity

    Time frame: 180 minutes after beverage consumption

    Urine Specific Gravity measured via refractometry.

  16. Urine Specific Gravity

    Time frame: 240 minutes after beverage consumption

    Urine Specific Gravity measured via refractometry.

  17. Urine Sodium

    Time frame: 0 minutes before beverage consumption

    Urine sodium will be measured in millimoles per kilogram of water

  18. Urine Sodium

    Time frame: 0 minutes after beverage consumption

    Urine sodium will be measured in milliosmoles per kilogram of water

  19. Urine Sodium

    Time frame: 60 minutes after beverage consumption

    Urine sodium will be measured in millimoles per kilogram of water

  20. Urine Sodium

    Time frame: 120 minutes after beverage consumption

    Urine sodium will be measured in milliosmoles per kilogram of water

  21. Urine Sodium

    Time frame: 180 minutes after beverage consumption

    Urine sodium will be measured in millimoles per kilogram of water

  22. Urine Sodium

    Time frame: 240 minutes after beverage consumption

    Urine sodium will be measured in millimoles per kilogram of water

  23. Urine Potassium

    Time frame: 0 minutes before beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  24. Urine Potassium

    Time frame: 0 minutes after beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  25. Urine Potassium

    Time frame: 60 minutes after beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  26. Urine Potassium

    Time frame: 120 minutes after beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  27. Urine Potassium

    Time frame: 180 minutes after beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  28. Urine Potassium

    Time frame: 240 minutes after beverage consumption

    Urine Potassium will be measured in millimoles per kilogram of water

  29. Body mass

    Time frame: 0 minutes before beverage consumption

    Body Mass in kilograms will be measured using a digital scale

  30. Body mass

    Time frame: 240 minutes after beverage consumption

    Body Mass in kilograms will be measured using a digital scale

  31. Body Water

    Time frame: 0 minutes before beverage consumption

    Body water will be determined using a digital bioelectrical impedance analysis scale.

  32. Body Water

    Time frame: 120 minutes after beverage consumption

    Body water will be determined using a digital bioelectrical impedance analysis scale.

  33. Body Water

    Time frame: 240 minutes after beverage consumption

    Body water will be determined using a digital bioelectrical impedance analysis scale.

Secondary outcomes

  1. Mood and Digestive Questionnaire

    Time frame: 0 minutes before beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.

  2. Mood and Digestive Questionnaire

    Time frame: 0 minutes after beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.

  3. Mood and Digestive Questionnaire

    Time frame: 60 minutes after beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.

  4. Mood and Digestive Questionnaire

    Time frame: 120 minutes after beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes being better outcome and higher scores for both negative mood attributes and digestive traits being worse.scale questionnaire with scale 0 (None) to 10 (Extreme)

  5. Mood and Digestive Questionnaire

    Time frame: 180 minutes after beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.

  6. Mood and Digestive Questionnaire

    Time frame: 240 minutes after beverage consumption

    Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.

  7. Diastolic Blood Pressure

    Time frame: 0 minutes before beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  8. Diastolic Blood Pressure

    Time frame: 0 minutes after beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  9. Diastolic Blood Pressure

    Time frame: 60 minutes after beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  10. Diastolic Blood Pressure

    Time frame: 120 minutes after beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  11. Diastolic Blood Pressure

    Time frame: 180 minutes after beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  12. Diastolic Blood Pressure

    Time frame: 240 minutes after beverage consumption

    Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  13. Systolic Blood Pressure

    Time frame: 0 minutes before beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  14. Systolic Blood Pressure

    Time frame: 0 minutes after beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  15. Systolic Blood Pressure

    Time frame: 60 minutes after beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  16. Systolic Blood Pressure

    Time frame: 120 minutes after beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  17. Systolic Blood Pressure

    Time frame: 180 minutes after beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  18. Systolic Blood Pressure

    Time frame: 240 minutes after beverage consumption

    Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff

  19. Heart Rate

    Time frame: 0 minutes before beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  20. Heart Rate

    Time frame: 0 minutes after beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  21. Heart Rate

    Time frame: 60 minutes after beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  22. Heart Rate

    Time frame: 120 minutes after beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  23. Heart Rate

    Time frame: 180 minutes after beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  24. Heart Rate

    Time frame: 240 minutes after beverage consumption

    Heart rate will be measured in beats per minute using an automated cuff

  25. Blood Glucose

    Time frame: 0 minutes before beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

  26. Blood Glucose

    Time frame: 40 minutes after beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

  27. Blood Glucose

    Time frame: 50 minutes after beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

  28. Blood Glucose

    Time frame: 60 minutes after beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

  29. Blood Glucose

    Time frame: 75 minutes after beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

  30. Blood Glucose

    Time frame: 90 minutes after beverage consumption

    Blood glucose will be measured in milligrams per deciliter using a glucometer

Study contacts

Contact information is provided by the study sponsor or research team.

Jacquelyn Pence, PhD

CONTACT

[email protected]

901-678-1547

Richard Bloomer, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Memphis

Other

Collaborators

  • PharmaLinea Ltd.

Registry information

Official study title

Comparison of the Beverage Hydration Index of Different Solutions

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 2, 2026
Registry last updated
Apr 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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