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OpenTrials
Completed

NCT Number: NCT00740168

Bevacizumab Treatment and Retinal Vessel Monitoring

Bevacizumab might influence the dynamic vessel function after being administered intravenously.

Completed

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Key information

Conditions

Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Autonomic lab (ANF)

Dresden, Saxony, 01307, Germany

About this study

By monitoring different vessel and circulation parameters (e.g. dynamic retinal vessel analyzer) the study will clarify the potential hemodynamic effects of bevacizumab.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who wish and need bevacizumab treatment for underlying disease

Exclusion criteria

  • previous bevacizumab treatment
  • known eye disease, eye surgery or eye trauma in history
  • myopia >-2.0 dpt
  • hyperopia > +2.0 dpt.
  • relevant media opacity of the lens
  • acute heart disease, ischemic insult, proven coronary heart disease
  • cardiac arrhythmia or vessel anomalies
  • seizure disorder or episode in history
  • migraine
  • treatment with corticosteroids within 4 weeks before study inclusion
  • intake of vasoactive drugs like AT-1 or glitazone
  • pregnancy

Treatment and study plan

bevacizumab treatment

Drug

single infusion 10 mg/kg

Other names: Avastin, ATC code: L01XC07, CAS Registry Number:216974-75-3, VEGF-inhibitor

Primary outcomes

  1. Diameter of retinal vessels and dynamic vessel reaction

    Time frame: Measurements before and after administration

Secondary outcomes

  1. Baroreflex sensitivity, heart frequence variability, reaction to handgrip test

    Time frame: Measurements before and after administration

Sponsors and collaborators

Lead sponsor

Technische Universität Dresden

Other

Registry information

Official study title

Analysis of Retinal Vessel Reaction and Monitoring of Circulation Parameters During Bevacizumab Therapy

Acronym: BevaRet

Important dates

Study start
2007
Primary completion
2008
Study completion
2009
First posted
Aug 22, 2008
Registry last updated
Jan 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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