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OpenTrials
Completed

NCT Number: NCT02821481

Beta-alanine and Elder Endurance

The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.

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Key information

Conditions

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Max Orovitz Laboratories

Coral Gables, Florida, 33146, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 60-90 years of age
  • Living independently (not residing in an assisted living facility)
  • Through testing are found not to have sarcopenia
  • Gait speed > 1 m/s
  • Skeletal Muscle Index > 37% in men and > 27.6 % in women
  • Exclusion Criteria
  • Responding with a "yes" to any question on the PAR-Q.
  • Are currently pregnant, or plan to try and become pregnant during the study
  • Functional impairments that could impede the person's ability to participate in a resistance training program
  • Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.
  • Are currently enrolled in a regular exercise program (more than once per week)
  • Current or recent smoker
  • Use of medication containing corticosteroids
  • Mini-mental score of 21 or below
  • Severe musculoskeletal impairment
  • Uncontrolled chronic disease
  • Major depression
  • Severe vestibular problems

Exclusion criteria

  • Adults unable to consent
  • Individuals who are not yet adults (infants, children, teenagers)
  • Pregnant women
  • Prisoners

Treatment and study plan

Beta-alanine

Dietary Supplement

Placebo

Dietary Supplement

Muscular endurance exercise

Behavioral

Primary outcomes

  1. Change in Performance of Daily Activities

    Time frame: baseline, 12 weeks

    Short Physical Functional Performance test

Secondary outcomes

  1. Change in Body Fat

    Time frame: baseline, 12 weeks

    Body fat assessment via bioimpedance

  2. Change in Muscular Endurance

    Time frame: baseline, 12 weeks

    20 repetitions to measure decline in muscular power across repetitions

  3. Change in Muscular Strength

    Time frame: baseline, 12 weeks

    Maximal weight that could be lifted one time (1RM)

Sponsors and collaborators

Lead sponsor

University of Miami

Other

Registry information

Official study title

The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jul 1, 2016
Registry last updated
Sep 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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